TELO2

Gene Symbol TELO2
Entrez Gene 9894
Alt Symbol CLK2, TEL2
Species Human
Gene Type protein-coding
Description telomere maintenance 2
Other Description TEL2, telomere maintenance 2, homolog|protein clk-2 homolog|telomere length regulation protein TEL2 homolog
Swissprots Q9BR21 D3DU73 O75168 Q7LDV4 Q9Y4R8
Accessions AAK61284 EAW85647 EAW85648 EAW85649 EAW85650 EAW85651 Q9Y4R8 AB014583 BAA31658 AK001786 BAG50974 AK302103 BAG63484 AL080126 CAB45724 AL137394 CAB70722 BC017188 AAH17188 BC028332 BQ446656 DB494123 XM_006720993 XP_006721056 XM_011522773 XP_011521075 XM_011522774 XP_011521076 XM_011522775 XP_011521077 XM_011522776 XP_011521078 XM_011522777 XP_011521079 XM_011522778 XP_011521080 XR_932982 XR_932983 NM_016111 NP_057195
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
Subcellular Location Cytoplasm. Membrane. Nucleus. Chromosome, telomere {ECO:0000305}.
Top Pathways Fanconi anemia pathway

TELO2 (Y-14) - sc-138069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TELO2 (F-15) - sc-138067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TELO2 antibody - ab122722 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122722, at 1/50 dilution, staining TELO2 in paraffin-embedded Human urinary bladder tissue by Immunohistochemistry.

Anti-TELO2 antibody - ab122711 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122711, at 1/50 dilution, staining TELO2 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

Anti-TELO2 antibody - C-terminal - ab182525 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TELO2 antibody - C-terminal (ab182525) at 1 µg/ml + HepG2 whole cell lysates at 10 µg

Anti-TELO2 Antibody (aa786-812, APC) - LS-C241699 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa786-812, FITC) - LS-C241703 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa786-812, AP) - LS-C241702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa786-812, Biotin) - LS-C241700 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa786-812, PE) - LS-C241704 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa792-822) - LS-C325663 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (aa786-812, Azide-free, HRP) - LS-C247046 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TELO2 Antibody (C-Terminus) - LS-C201912 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. TELO2 antibody dilution 1.0 ug/ml.

Anti-TELO2 Antibody (aa786-812) - LS-C161799 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TELO2 Antibody IHC of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TELO2 antibody produced in rabbit - HPA041473 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TELO2: <B>Cat. No. HPA041473</B>: Immunohistochemical staining of human urinary bladder shows cytoplasmic and nuclear positivity in urothelial cells.

Anti-TELO2 antibody produced in rabbit - HPA041348 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TELO2: <B>Cat. No. HPA041348</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Anti-TELO2 (666-678) antibody produced in rabbit - SAB1100719 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-TELO2 (666-678) : <B>Cat. No. SAB1100719</B>: Immunofluorescence of HUVEC cells using TELO2 (666-678) , Cat. No. SAB1100719 (red) at a 1:200 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-TELO2 (36-47) antibody produced in rabbit - SAB1100718 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-TELO2 (36-47) : <B>Cat. No. SAB1100718</B>: Immunofluorescence of HUVEC cells using TELO2 (36-47) , Cat. No. SAB1100718 (red) at a 1:200 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

CLK2 Antibody - N-terminal region (ARP52016_P050) - ARP52016_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TELO2 Antibody - C-terminal region (ARP71738_P050) - ARP71738_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TELO2 Antibody - C-terminal region (OAAB02225) - OAAB02225 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

TELO2-Antibody-C-term - AP4808b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TELO2 Antibody (C-term) (Cat. #AP4808b) in K562 cell line lysates (35ug/lane). TELO2 (arrow) was detected using the purified Pab.

CLK2 antibody [N3C3] - GTX107930 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-CLK2 antibody [N3C3] used in Western blot. GTX107930

CLK2 antibody - 70R-16455 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -CLK2 (Dual Specificity Protein Kinase CLK2, CDC-like Kinase 2) - 125083 from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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