| Gene Symbol |
TELO2
|
| Entrez Gene |
9894
|
| Alt Symbol |
CLK2, TEL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
telomere maintenance 2
|
| Other Description |
TEL2, telomere maintenance 2, homolog|protein clk-2 homolog|telomere length regulation protein TEL2 homolog
|
| Swissprots |
Q9BR21 D3DU73 O75168 Q7LDV4 Q9Y4R8
|
| Accessions |
AAK61284 EAW85647 EAW85648 EAW85649 EAW85650 EAW85651 Q9Y4R8 AB014583 BAA31658 AK001786 BAG50974 AK302103 BAG63484 AL080126 CAB45724 AL137394 CAB70722 BC017188 AAH17188 BC028332 BQ446656 DB494123 XM_006720993 XP_006721056 XM_011522773 XP_011521075 XM_011522774 XP_011521076 XM_011522775 XP_011521077 XM_011522776 XP_011521078 XM_011522777 XP_011521079 XM_011522778 XP_011521080 XR_932982 XR_932983 NM_016111 NP_057195
|
| Function |
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
|
| Subcellular Location |
Cytoplasm. Membrane. Nucleus. Chromosome, telomere {ECO:0000305}.
|
| Top Pathways |
Fanconi anemia pathway
|
![Western Blot: TEL2 Overexpression Lysate (Adult Normal) [NBL1-16813] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TEL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1885_TEL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16813-img0001.jpg)