TELO2

Gene Symbol TELO2
Entrez Gene 9894
Alt Symbol CLK2, TEL2
Species Human
Gene Type protein-coding
Description telomere maintenance 2
Other Description TEL2, telomere maintenance 2, homolog|protein clk-2 homolog|telomere length regulation protein TEL2 homolog
Swissprots Q9BR21 D3DU73 O75168 Q7LDV4 Q9Y4R8
Accessions AAK61284 EAW85647 EAW85648 EAW85649 EAW85650 EAW85651 Q9Y4R8 AB014583 BAA31658 AK001786 BAG50974 AK302103 BAG63484 AL080126 CAB45724 AL137394 CAB70722 BC017188 AAH17188 BC028332 BQ446656 DB494123 XM_006720993 XP_006721056 XM_011522773 XP_011521075 XM_011522774 XP_011521076 XM_011522775 XP_011521077 XM_011522776 XP_011521078 XM_011522777 XP_011521079 XM_011522778 XP_011521080 XR_932982 XR_932983 NM_016111 NP_057195
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
Subcellular Location Cytoplasm. Membrane. Nucleus. Chromosome, telomere {ECO:0000305}.
Top Pathways Fanconi anemia pathway

TELO2 CRISPR/Cas9 KO Plasmid (h) - sc-409152 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 HDR Plasmid (h) - sc-409152-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 Double Nickase Plasmid (h) - sc-409152-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 Double Nickase Plasmid (h2) - sc-409152-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 CRISPR Activation Plasmid (h) - sc-409152-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 CRISPR Activation Plasmid (h2) - sc-409152-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 Lentiviral Activation Particles (h) - sc-409152-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 Lentiviral Activation Particles (h2) - sc-409152-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TELO2 siRNA (h) - sc-93308 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TELO2 shRNA Plasmid (h) - sc-93308-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TELO2 shRNA (h) Lentiviral Particles - sc-93308-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLK2 RNAi - H00001196-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU156541 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21213 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21213 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05039 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05039

TELO2 siRNA (Human) - CRH6639 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TELO2 - MBS8230069 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TELO2 (NM_016111.3) - SHH425657 from Creative biogene

Category siRNA
Species Reactivities Human

Human TELO2 siRNA - orb267141 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TELO2 shRNA Plasmid (Human) - CHH6639 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TELO2 miRNA 3'UTR clone - MiUTR3H-11668 from Creative biogene

Species Reactivities Human
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