| Gene Symbol |
SLC9A3R2
|
| Entrez Gene |
9351
|
| Alt Symbol |
E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
|
| Other Description |
NHE3 kinase A regulatory protein E3KARP|NHE3 regulatory factor 2|Na(+)/H(+) exchange regulatory cofactor NHE-RF2|SRY-interacting protein 1|sodium/hydrogen exchanger 3 kinase A regulatory protein|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2|solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2|solute carrier family 9 isoform A3 regulatory factor 2|tyrosine kinase activator protein 1
|
| Swissprots |
O00556 D3DU84 Q15599 H3BSV6 D3DU85 Q3KQY7 O00272
|
| Accessions |
AAC34208 BAA32696 BAA33216 EAW85563 EAW85564 EAW85565 EAW85566 Q15599 AF004900 AAC63061 AF035771 AAC52090 BC014513 AAH14513 BC069014 AAH69014 BC106001 AAI06002 BQ447156 BQ687174 BX377861 CB961565 DB495688 U82108 AAB53042 Z50150 CAA90511 XM_005255702 XP_005255759 XM_005255703 XP_005255760 XM_006720981 XP_006721044 NM_001130012 NP_001123484 NM_001252073 NP_001239002 NM_001252075 NP_001239004 NM_001252076 NP_001239005 NM_004785 NP_004776
|
| Function |
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:9096337}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:9054412}; Peripheral membrane protein {ECO:0000269|PubMed:9054412}. Nucleus {ECO:0000269|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:9054412, ECO:0000269|PubMed:9096337}.
|
| Top Pathways |
Aldosterone-regulated sodium reabsorption
|