SLC9A3R2

Gene Symbol SLC9A3R2
Entrez Gene 9351
Alt Symbol E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1
Species Human
Gene Type protein-coding
Description solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Other Description NHE3 kinase A regulatory protein E3KARP|NHE3 regulatory factor 2|Na(+)/H(+) exchange regulatory cofactor NHE-RF2|SRY-interacting protein 1|sodium/hydrogen exchanger 3 kinase A regulatory protein|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2|solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2|solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2|solute carrier family 9 isoform A3 regulatory factor 2|tyrosine kinase activator protein 1
Swissprots O00556 D3DU84 Q15599 H3BSV6 D3DU85 Q3KQY7 O00272
Accessions AAC34208 BAA32696 BAA33216 EAW85563 EAW85564 EAW85565 EAW85566 Q15599 AF004900 AAC63061 AF035771 AAC52090 BC014513 AAH14513 BC069014 AAH69014 BC106001 AAI06002 BQ447156 BQ687174 BX377861 CB961565 DB495688 U82108 AAB53042 Z50150 CAA90511 XM_005255702 XP_005255759 XM_005255703 XP_005255760 XM_006720981 XP_006721044 NM_001130012 NP_001123484 NM_001252073 NP_001239002 NM_001252075 NP_001239004 NM_001252076 NP_001239005 NM_004785 NP_004776
Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:9096337}.
Subcellular Location Endomembrane system {ECO:0000269|PubMed:9054412}; Peripheral membrane protein {ECO:0000269|PubMed:9054412}. Nucleus {ECO:0000269|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9054412, ECO:0000269|PubMed:9096337}.
Top Pathways Aldosterone-regulated sodium reabsorption

human SLC9A3R2 ORF clone - CDCH080310 from Creative Biomart

Species Human
Accession NM_001130012

human SLC9A3R2 ORF clone - CDCH080311 from Creative Biomart

Species Human
Accession NM_001130012

human SLC9A3R2 ORF clone - CDCH080312 from Creative Biomart

Species Human
Accession NM_001130012

human SLC9A3R2 ORF clone - CDCH080313 from Creative Biomart

Species Human
Accession NM_001130012

Human SLC9A3R2 ORF Clone(NM_001130012.2) - CDCL176250 from Creative Biomart

Species Human
Accession NM_001130012.2
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