VTCN1

Gene Symbol VTCN1
Entrez Gene 79679
Alt Symbol B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
Species Human
Gene Type protein-coding
Description V-set domain containing T cell activation inhibitor 1
Other Description B7 family member, H4|B7 homolog 4|B7 superfamily member 1|T cell costimulatory molecule B7x|T-cell costimulatory molecule B7x|V-set domain-containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4
Swissprots Q45VN0 Q6P097 Q7Z7D3 Q9H6B2 Q5WPZ3 Q0GN76
Accessions EAW56671 EAW56672 EAW56673 Q7Z7D3 AI686571 AK026071 BAB15349 AK225413 AK303466 BAH13967 AK310812 AY280972 AAP37283 AY346100 AAQ24206 AY358352 AAQ88718 AY442303 AAS13400 BC065717 AAH65717 BC074729 AAH74729 BX648021 CN259811 DB198367 DC347131 DQ103757 AAZ17406 DQ836392 ABI16083 XM_011542143 XP_011540445 XM_011542144 XP_011540446 XM_011542145 XP_011540447 NM_001253849 NP_001240778 NM_001253850 NP_001240779 NM_024626 NP_078902 NR_045603 NR_045604
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.
Subcellular Location Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
Tissue Specificity Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
Top Pathways Cell adhesion molecules (CAMs)

B7-H4 (D1M8I) XP ® Rabbit mAb - 14572 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1M8I
Western blot analysis of extracts from SK-BR-3, T-47D, and NCI-H1299 cells using B7-H4 (D1M8I) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

B7-H4 (H-108) - sc-68872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
B7-H4 (H-108): sc-68872. Western blot analysis of B7-H4 expression in CTLL-2 whole cell lysate (A) and mouse liver tissue extract (B).

B7-H4 (G-18) - sc-68254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-B7H4 antibody - ab176146 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-B7H4 antibody (ab176146) at 1 µg/ml + EL4 cell lysate at 15 µg

Anti-B7H4 antibody [EP1165] - ab108336 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1165
All lanes : Anti-B7H4 antibody [EP1165] (ab108336) at 1/10000 dilutionLane 1 : Human fetal spleen lysateLane 2 : Human fetal thymus lysateLane 3 : SKBR3 lysateLysates/proteins at 10 µg per lane.

Anti-B7H4 antibody [H74] - ab110160 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone H74
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab110160 at a concentration of 20 µg/ml.

Anti-B7H4 antibody [H74] - Low endotoxin, Azide free - ab171280 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone H74
Flow cytometric analysis of non-transfected (left) and Human B7H4 transfected (right) 293T cells with 0.125 μg of Mouse IgG1 K Isotype Control (open histogram) or 0.125 μg of ab171280 (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE. Total cells were used for analysis.

Anti-B7H4 antibody [MIH43] - ab110221 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MIH43
ab110221 staining B7H4 in human breast carcinoma tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-B7H4 antibody [MIH43] (FITC) - ab110222 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MIH43
ab110222 staining B7H4 in peripheral human blood monocytes by Flow Cytometry.

Anti-B7H4 antibody [MIH43] (Phycoerythrin) - ab72708 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MIH43

Anti-VTCN1 / B7-H4 Antibody (clone H74) IHC-plus™ - LS-B4055 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone H74
Anti-VTCN1 / B7-H4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4055 concentration 20 ug/ml.

Anti-VTCN1 / B7-H4 Antibody (Biotin) - LS-C211330 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (FITC) - LS-C211329 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa72-100, AP) - LS-C242662 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa138-149) - LS-C55682 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-VTCN1 / B7-H4 Antibody (aa72-100, FITC) - LS-C242663 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa72-100, Biotin) - LS-C242665 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa72-100, APC) - LS-C242664 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa72-100, Azide-free, HRP) - LS-C247239 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa72-100, PE) - LS-C242670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa34-147, Biotin) - LS-C298073 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa34-147, Biotin) - LS-C299310 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-VTCN1 / B7-H4 Antibody (aa153-241, Biotin) - LS-C299534 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa34-147, FITC) - LS-C301934 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VTCN1 / B7-H4 Antibody (aa34-147, FITC) - LS-C303498 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
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