VTCN1

Gene Symbol	VTCN1
Entrez Gene	79679
Alt Symbol	B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
Species	Human
Gene Type	protein-coding
Description	V-set domain containing T cell activation inhibitor 1
Other Description	B7 family member, H4|B7 homolog 4|B7 superfamily member 1|T cell costimulatory molecule B7x|T-cell costimulatory molecule B7x|V-set domain-containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4
Swissprots	Q45VN0 Q6P097 Q7Z7D3 Q9H6B2 Q5WPZ3 Q0GN76
Accessions	EAW56671 EAW56672 EAW56673 Q7Z7D3 AI686571 AK026071 BAB15349 AK225413 AK303466 BAH13967 AK310812 AY280972 AAP37283 AY346100 AAQ24206 AY358352 AAQ88718 AY442303 AAS13400 BC065717 AAH65717 BC074729 AAH74729 BX648021 CN259811 DB198367 DC347131 DQ103757 AAZ17406 DQ836392 ABI16083 XM_011542143 XP_011540445 XM_011542144 XP_011540446 XM_011542145 XP_011540447 NM_001253849 NP_001240778 NM_001253850 NP_001240779 NM_024626 NP_078902 NR_045603 NR_045604
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.
Subcellular Location	Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
Tissue Specificity	Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VTCN1 overexpression lysate - LY403017 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

VTCN1 293 Cell Lysate - 402625 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

B7-H4 Overexpression Lysate (Native) - NBL1-17768 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

VTCN1 Over-expression Lysate Product - GWB-BEBACE from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human B7-H4 / B7S1 / B7x HEK293 Cell Lysate (WB positive control) - 10738-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human B7-H4 / B7S1 / B7x HEK293 Cell Lysate (WB positive control) - 10738-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human B7S1 Human Cells Transfected Lysate (positive control) (denatured) - orb174249 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human B7S1 Human Cells Transfected Lysate (positive control) (denatured) - orb174573 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human VTCN1 Knockdown Stable Cell Line - CSC-DC017353 from Creative biogene Category Cell Line Species Human

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