VTCN1

Gene Symbol VTCN1
Entrez Gene 79679
Alt Symbol B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
Species Human
Gene Type protein-coding
Description V-set domain containing T cell activation inhibitor 1
Other Description B7 family member, H4|B7 homolog 4|B7 superfamily member 1|T cell costimulatory molecule B7x|T-cell costimulatory molecule B7x|V-set domain-containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4
Swissprots Q45VN0 Q6P097 Q7Z7D3 Q9H6B2 Q5WPZ3 Q0GN76
Accessions EAW56671 EAW56672 EAW56673 Q7Z7D3 AI686571 AK026071 BAB15349 AK225413 AK303466 BAH13967 AK310812 AY280972 AAP37283 AY346100 AAQ24206 AY358352 AAQ88718 AY442303 AAS13400 BC065717 AAH65717 BC074729 AAH74729 BX648021 CN259811 DB198367 DC347131 DQ103757 AAZ17406 DQ836392 ABI16083 XM_011542143 XP_011540445 XM_011542144 XP_011540446 XM_011542145 XP_011540447 NM_001253849 NP_001240778 NM_001253850 NP_001240779 NM_024626 NP_078902 NR_045603 NR_045604
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.
Subcellular Location Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
Tissue Specificity Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
Top Pathways Cell adhesion molecules (CAMs)

PathScan ® Total B7-H4 Sandwich ELISA Kit - 14520 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

Human VTCN1 / B7-H4 ELISA Kit (Sandwich ELISA) - LS-F7262 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

B7-H4, Human, ELISA Kit - CSB-E15013h from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 1.95ng/ml
Range 7.8ng/ml-500 ng/ml

V-Set Domain Containing T-Cell Activation Inhibitor 1 (VTCN1), Human, ELISA Kit - SEK032Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.054ng/mL
Range 0.156-10ng/mL

V-set domain-containing T-cell activation inhibitor 1, VTCN1, Human, ELISA Kit - E1079h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 7.8-500 ng/mL

Costimulatory Molecules B7H4, ELISA Kit - MBS020231 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS051212 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS006690 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS037947 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS036926 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS022849 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS086097 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS020084 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 ng/ml.
Range 6.25 - 200 ng/ml.

Costimulatory Molecules B7H4, ELISA Kit - MBS013959 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 ng/ml.
Range 3.12 ng/ml ~ 100 ng/ml.

Costimulatory Molecules B7H4, ELISA Kit - MBS005023 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS088229 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS024747 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS018107 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0ng/ml.
Range 5ng/ml-160ng/ml.

Costimulatory Molecules B7H4, ELISA Kit - MBS023232 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS043725 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS104404 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS023273 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS024297 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS041967 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Costimulatory Molecules B7H4, ELISA Kit - MBS027379 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more