| Gene Symbol |
VTCN1
|
| Entrez Gene |
79679
|
| Alt Symbol |
B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
V-set domain containing T cell activation inhibitor 1
|
| Other Description |
B7 family member, H4|B7 homolog 4|B7 superfamily member 1|T cell costimulatory molecule B7x|T-cell costimulatory molecule B7x|V-set domain-containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4
|
| Swissprots |
Q45VN0 Q6P097 Q7Z7D3 Q9H6B2 Q5WPZ3 Q0GN76
|
| Accessions |
EAW56671 EAW56672 EAW56673 Q7Z7D3 AI686571 AK026071 BAB15349 AK225413 AK303466 BAH13967 AK310812 AY280972 AAP37283 AY346100 AAQ24206 AY358352 AAQ88718 AY442303 AAS13400 BC065717 AAH65717 BC074729 AAH74729 BX648021 CN259811 DB198367 DC347131 DQ103757 AAZ17406 DQ836392 ABI16083 XM_011542143 XP_011540445 XM_011542144 XP_011540446 XM_011542145 XP_011540447 NM_001253849 NP_001240778 NM_001253850 NP_001240779 NM_024626 NP_078902 NR_045603 NR_045604
|
| Function |
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.
|
| Subcellular Location |
Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
|
| Tissue Specificity |
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|