| Gene Symbol |
FIGN
|
| Entrez Gene |
55137
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fidgetin
|
| Other Description |
-
|
| Swissprots |
B3KWM0 Q9NVZ9 Q5HY92 Q9H6M5
|
| Accessions |
AAX81992 CAK32384 EAX11345 Q5HY92 AK001267 BAA91590 AK025747 BAB15231 AK125324 BAG54182 BC148649 AAI48650 BC156958 AAI56959 BX649105 CAI45980 EU832143 ACE87493 EU832236 ACE86806 XM_005246661 XP_005246718 XM_005246662 XP_005246719 XM_011511389 XP_011509691 XM_011511390 XP_011509692 XM_011511391 XP_011509693 NM_018086 NP_060556
|
| Function |
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. {ECO:0000269|PubMed:22672901}.
|
| Subcellular Location |
Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22672901}. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
|