| Gene Symbol |
PPAPDC2
|
| Entrez Gene |
403313
|
| Alt Symbol |
PDP1, PSDP, bA6J24.6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidic acid phosphatase type 2 domain containing 2
|
| Other Description |
PPAP2 domain-containing protein 2|phosphatidic acid phosphatase type 2 domain-containing protein 2|polyisoprenoid diphosphate phosphatase type 1|presqualene diphosphate phosphatase
|
| Swissprots |
Q5JVJ6 Q8IY26 B3KY05 Q8NCK9
|
| Accessions |
EAW58785 Q8IY26 AK074672 AK128369 BAG54667 AK296773 BAG59352 BC036833 BC038108 AAH38108 BU632000 DA416947 NM_203453 NP_982278
|
| Function |
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. {ECO:0000269|PubMed:16464866}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain. {ECO:0000269|PubMed:16464866}.
|