Gene Symbol | PPAPDC2 |
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Entrez Gene | 403313 |
Alt Symbol | PDP1, PSDP, bA6J24.6 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidic acid phosphatase type 2 domain containing 2 |
Other Description | PPAP2 domain-containing protein 2|phosphatidic acid phosphatase type 2 domain-containing protein 2|polyisoprenoid diphosphate phosphatase type 1|presqualene diphosphate phosphatase |
Swissprots | Q5JVJ6 Q8IY26 B3KY05 Q8NCK9 |
Accessions | EAW58785 Q8IY26 AK074672 AK128369 BAG54667 AK296773 BAG59352 BC036833 BC038108 AAH38108 BU632000 DA416947 NM_203453 NP_982278 |
Function | Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. {ECO:0000269|PubMed:16464866}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain. {ECO:0000269|PubMed:16464866}. |
PPAPDC2 (N-14) - sc-163253 from Santa Cruz Biotechnology
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Anti-PPAPDC2 antibody - ab60196 from Abcam
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Anti-PPAPDC2 Antibody (C-Terminus) IHC-plus⢠- LS-B5057 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody - LS-C26842 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, AP) - LS-C239328 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, APC) - LS-C239329 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, Biotin) - LS-C239330 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, FITC) - LS-C239331 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, PE) - LS-C239336 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96, Azide-free, HRP) - LS-C248530 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa69-96) - LS-C324203 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (N-Terminus) - LS-C111761 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa71-120) - LS-C111762 from LifeSpan Bioscience
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Anti-PPAPDC2 Antibody (aa70-96) - LS-C158701 from LifeSpan Bioscience
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PDP1/PPAPDC2 Antibody - NBP1-76245 from Novus Biologicals
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PDP1/PPAPDC2 Antibody - NBP1-60021 from Novus Biologicals
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PDP1/PPAPDC2 Antibody - NBP1-60022 from Novus Biologicals
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Anti-PPAPDC2 antibody produced in rabbit - SAB3500287 from Sigma-Aldrich
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Anti-PPAPDC2, (N-terminal) antibody produced in rabbit - SAB2103878 from Sigma-Aldrich
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Anti-PPAPDC2, (N-terminal) antibody produced in rabbit - SAB2103877 from Sigma-Aldrich
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Anti-PPAPDC2 antibody produced in rabbit - HPA018096 from Sigma-Aldrich
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PPAPDC2 antibody - N-terminal region (ARP55973_P050) - ARP55973_P050 from Aviva Systems Biology
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PPAPDC2 antibody - N-terminal region (ARP55974_P050) - ARP55974_P050 from Aviva Systems Biology
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PPAPDC2-Antibody-N-term - AP17641a from Abgent, a WuXi AppTec company
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PPAPDC2 Antibody - N-terminal region (OAAB13072) - OAAB13072 from Aviva Systems Biology
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