NKX3-1

Gene Symbol NKX3-1
Entrez Gene 4824
Alt Symbol BAPX2, NKX3, NKX3.1, NKX3A
Species Human
Gene Type protein-coding
Description NK3 homeobox 1
Other Description NK homeobox, family 3, A|NK3 transcription factor homolog A|NK3 transcription factor related, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1
Swissprots Q9H2P4 Q9H2P7 Q9H2P6 Q9H2P5 Q9HBG0 O15465 Q99801
Accessions EAW63613 Q99801 AF247704 AAG09781 AF249669 AAG39735 AF249670 AAG39736 AF249671 AAG39737 AF249672 AAG39738 BC074863 AAH74863 BC074864 AAH74864 BC111569 BC111574 BF511129 EU446642 ABZ92171 U80669 AAB38747 U91540 AAB68662 NM_001256339 NP_001243268 NM_006167 NP_006158 NR_046072
Function Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:11137288}.
Tissue Specificity Highly expressed in the prostate and, at a lower level, in the testis. {ECO:0000269|PubMed:9226374, ECO:0000269|PubMed:9537602}.
Top Pathways Prostate cancer

Nkx-3.1 (H-50) - sc-25405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Nkx-3.1 (H-50): sc-25405. Western blot analysis of human recombinant Nkx-3.1 fusion protein.

Nkx-3.1 (N-15) - sc-15021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Nkx-3.1 expression in LNCaP whole cell lysate. Antibodies used: Nkx-3.1 (N-15): sc-15021 (A) and Nkx-3.1 (T-19): sc-15022 (B).

Nkx-3.1 (T-19) - sc-15022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Nkx-3.1 expression in LNCaP whole cell lysate. Antibodies tested include Nkx-3.1 (N-15): sc-15021 (A) and Nkx-3.1 (T-19): sc-15022 (B).

Nkx-3.1 (820C3a) - sc-81340 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Nkx-3.1 (820C3a): sc-81340 Western Blot analysis of human recombinant Nkx-3.1 fusion protein.

Nkx-3.1 (A-3) - sc-393190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nkx-3.1 (A-3): sc-393190. Western blot analysis of Nkx-3.1 expression in LNCaP (A) and NTERA-2 cl.D1 (B) whole cell lysates and human colon tissue extract (C).

Anti-Nkx3.1 antibody - ab55781 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Nkx3.1 antibody - ab131626 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Nkx3.1 antibody - ab58382 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab58382 at 1/50 dilution staining Nkx3.1 in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-Nkx3.1 antibody - ab184628 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Nkx3.1 antibody (ab184628) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

Anti-Nkx3.1 antibody - ab33247 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Nkx3.1 antibody (ab33247) at 1/5000 dilution + 250 ng of purified recombinant HIS-tagged NKX3.1 full length protein (36kDa).SecondaryGoat anti-rabbit IgG HRP conjugatedat 1/5000 dilution for 30 minutes.developed using the ECL technique

Anti-Nkx3.1 antibody - ab41856 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
This image shows human prostate stained with ab41856 at 1/25 dilution.

Anti-Nkx3.1 antibody - ab83973 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Nkx3.1 antibody (ab83973) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Nkx3.1 antibody [4H4] - ab96482 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H4
Anti-Nkx3.1 antibody [4H4] (ab96482) at 1/500 dilution + LNCaP cell lysate

Anti-Nkx3.1 antibody [820C3a] - ab53237 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 820C3a
Anti-Nkx3.1 antibody [820C3a] (ab53237) + immunised recombinant protein fragment

Anti-Nkx3.1 antibody [EPR14970] - ab186413 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14970
Flow cytometric analysis of paraformaldehyde fixed PC-3 cells labeling Nkx3.1 with ab186413 at 1:230 dilution and Goat anti-rabbit IgG (FITC) at 1/150.

Anti-Nkx3.1 antibody [EPR16653] - ab196020 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16653
Anti-Nkx3.1 antibody [EPR16653] (ab196020) at 1/1000 dilution + Human prostate lysate at 10 µgSecondaryAnti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Anti-Nkx3.1 antibody, prediluted - ab41861 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Ab41861 staining human Nkx3.1 in human prostrate by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-NKX3-1 Antibody (clone 2A3) - LS-C339482 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NKX3-1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NKX3-1.

Anti-NKX3-1 Antibody (clone 7F6) - LS-C339483 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7F6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NKX3-1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NKX3-1.

Anti-NKX3-1 Antibody (clone 4C11) - LS-C339460 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NKX3-1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NKX3-1.

Anti-NKX3-1 Antibody (clone 4B4) - LS-C339464 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NKX3-1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NKX3-1.

Anti-NKX3-1 Antibody (clone 2D2) - LS-C339486 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D2
IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-NKX3-1 Antibody (clone 2A5) - LS-C339484 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A5
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-NKX3-1 Antibody (clone 8B2) - LS-C339518 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8B2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NKX3-1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NKX3-1.

Anti-NKX3-1 Antibody (aa118-145) IHC-plus™ - LS-B11115 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-NKX3-1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11115 dilution 1:100.
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