Gene Symbol | NKX3-1 |
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Entrez Gene | 4824 |
Alt Symbol | BAPX2, NKX3, NKX3.1, NKX3A |
Species | Human |
Gene Type | protein-coding |
Description | NK3 homeobox 1 |
Other Description | NK homeobox, family 3, A|NK3 transcription factor homolog A|NK3 transcription factor related, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1 |
Swissprots | Q9H2P4 Q9H2P7 Q9H2P6 Q9H2P5 Q9HBG0 O15465 Q99801 |
Accessions | EAW63613 Q99801 AF247704 AAG09781 AF249669 AAG39735 AF249670 AAG39736 AF249671 AAG39737 AF249672 AAG39738 BC074863 AAH74863 BC074864 AAH74864 BC111569 BC111574 BF511129 EU446642 ABZ92171 U80669 AAB38747 U91540 AAB68662 NM_001256339 NP_001243268 NM_006167 NP_006158 NR_046072 |
Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:11137288}. |
Tissue Specificity | Highly expressed in the prostate and, at a lower level, in the testis. {ECO:0000269|PubMed:9226374, ECO:0000269|PubMed:9537602}. |
Top Pathways | Prostate cancer |
Human Nkx3.1 full length protein - ab139222 from Abcam
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Human Nkx3.1 full length protein - ab134861 from Abcam
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Human Nkx3.1 protein fragment - ab114523 from Abcam
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NKX3-1 Antibody Blocking Peptide - LS-E4805 from LifeSpan Bioscience
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NKX3-1 Antibody Blocking Peptide - LS-E11200 from LifeSpan Bioscience
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NKX3-1 Antibody Blocking Peptide - LS-E13951 from LifeSpan Bioscience
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NKX3-1 Antibody Blocking Peptide - LS-E13318 from LifeSpan Bioscience
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NKX3-1 Antibody Blocking Peptide - LS-E6543 from LifeSpan Bioscience
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NKX3-1 Antibody Blocking Peptide - LS-E9892 from LifeSpan Bioscience
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NKX3.1 Partial Recombinant Protein - H00004824-Q01 from Novus Biologicals
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Recombinant Human NKX3.1 Protein - NBP2-23290 from Novus Biologicals
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NKX3-1-Antibody-C-term-Blocking-Peptide - BP17186b from Abgent, a WuXi AppTec company
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NKX3-1-Antibody-Center-Blocking-Peptide - BP8996c from Abgent, a WuXi AppTec company
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Human NKX3-1 protein - orb191094 from Biorbyt
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NKX3-1 protein (His tag) - 30R-2946 from Fitzgerald
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NKX3-1 Blocking Peptide - abx063007 from Abbexa
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NKX3-1 (1-234, His-tag) - AR50706PU-N from Acris Antibodies
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NKX3-1 (1-234, His-tag) - AR50706PU-S from Acris Antibodies
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NKX3-1 - H00004824-Q01-10 from Acris Antibodies
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NKX3-1 - H00004824-Q01-25 from Acris Antibodies
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NKX3-1, 1-234aa, Human, His tag, E.coli - 01-P1882 from ARP American Research Products
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NKX3-1 fusion protein - Ag17305 from Proteintech Group
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NKX3-1 fusion protein - ag4070 from Proteintech Group
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NKX3-1 fusion protein - Ag14496 from Proteintech Group
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NKX3-1 fusion protein - Ag17640 from Proteintech Group
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