| Gene Symbol |
NKX3-1
|
| Entrez Gene |
4824
|
| Alt Symbol |
BAPX2, NKX3, NKX3.1, NKX3A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NK3 homeobox 1
|
| Other Description |
NK homeobox, family 3, A|NK3 transcription factor homolog A|NK3 transcription factor related, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1
|
| Swissprots |
Q9H2P4 Q9H2P7 Q9H2P6 Q9H2P5 Q9HBG0 O15465 Q99801
|
| Accessions |
EAW63613 Q99801 AF247704 AAG09781 AF249669 AAG39735 AF249670 AAG39736 AF249671 AAG39737 AF249672 AAG39738 BC074863 AAH74863 BC074864 AAH74864 BC111569 BC111574 BF511129 EU446642 ABZ92171 U80669 AAB38747 U91540 AAB68662 NM_001256339 NP_001243268 NM_006167 NP_006158 NR_046072
|
| Function |
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:11137288}.
|
| Tissue Specificity |
Highly expressed in the prostate and, at a lower level, in the testis. {ECO:0000269|PubMed:9226374, ECO:0000269|PubMed:9537602}.
|
| Top Pathways |
Prostate cancer
|
![Western Blot: Nkx3.1 Overexpression Lysate (Adult Normal) [NBL1-13662] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Nkx3.1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1386_Nkx3.1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13662-img0002.jpg)