HCN4

Gene Symbol	HCN4
Entrez Gene	10021
Alt Symbol	SSS2
Species	Human
Gene Type	protein-coding
Description	hyperpolarization activated cyclic nucleotide gated potassium channel 4
Other Description	hyperpolarization activated cyclic nucleotide-gated cation channel 4|hyperpolarization activated cyclic nucleotide-gated potassium channel 4|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Swissprots	Q9UMQ7 Q9Y3Q4
Accessions	CCF23300 EAW77925 Q9Y3Q4 AJ132429 CAB42604 AJ238850 CAB52754 BC156298 AAI56299 BC172471 AAI72471 BM979827 BP291686 DQ854814 XM_011521148 XP_011519450 NM_005477 NP_005468
Function	Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}; Multi- pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}.
Tissue Specificity	Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953}.
Top Pathways	cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HCN4 ELISA Kit (Competitive EIA) - LS-F11611 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, HCN4, Human, ELISA Kit - E13654h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit - MBS281542 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat HCN4 ELISA Kit (Custom ELISA) - LS-F17035 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Mouse HCN4 ELISA Kit (Custom ELISA) - LS-F17036 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Rabbit HCN4 ELISA Kit - LS-F17037 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit - MBS288155 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/ml -10.0 ng/ml.

Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit - abx250819 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) - SEH925Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) ELISA Kit - EKU09254 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.122 ng/mL Range 0.312-20 ng/mL

Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit - EKE53257 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.098 ng/ml Range 0.312-20 ng/mL

HCN4 - EKH3066 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

HCN4 ELISA Kit (Human) : 96 Wells (OKEH02314) - OKEH02314 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.098 ng/mL Range 0.312 - 20 ng/mL

Custom Human HCN4 ELISA - ELH-HCN4-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human HCN4 ELISA Kit - E019173 from Biobool Category ELISA Kit Sensitivity 0.122ng/mL.

Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit - EK3269 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.098ng/ml Range 0.312-20 ng/mL

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4, ELISA Kit - MBS2031959 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.122ng/mL. Range 0.312-20ng/mL. The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL.

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit - MBS2880266 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.31 ng/mL -20.0 ng/mL.

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit - MBS9427103 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.098ng/mL Range 0.312-20 ng/mL

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit - MBS761257 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Human HCN4 ELISA Kit (Sandwich ELISA) - LS-F39079 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.122 Range 0.312-20 ng/ml

Custom Human HCN4 ELISA Kit - orb384614 from Biorbyt Category ELISA Kit

Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 (HCN4), ELISA Kit - MBS9907912 from MyBioSource Category ELISA Kit

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