| Gene Symbol |
HCN4
|
| Entrez Gene |
10021
|
| Alt Symbol |
SSS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyperpolarization activated cyclic nucleotide gated potassium channel 4
|
| Other Description |
hyperpolarization activated cyclic nucleotide-gated cation channel 4|hyperpolarization activated cyclic nucleotide-gated potassium channel 4|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
|
| Swissprots |
Q9UMQ7 Q9Y3Q4
|
| Accessions |
CCF23300 EAW77925 Q9Y3Q4 AJ132429 CAB42604 AJ238850 CAB52754 BC156298 AAI56299 BC172471 AAI72471 BM979827 BP291686 DQ854814 XM_011521148 XP_011519450 NM_005477 NP_005468
|
| Function |
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}; Multi- pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}.
|
| Tissue Specificity |
Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953}.
|
| Top Pathways |
cAMP signaling pathway
|