HCN4

Gene Symbol HCN4
Entrez Gene 10021
Alt Symbol SSS2
Species Human
Gene Type protein-coding
Description hyperpolarization activated cyclic nucleotide gated potassium channel 4
Other Description hyperpolarization activated cyclic nucleotide-gated cation channel 4|hyperpolarization activated cyclic nucleotide-gated potassium channel 4|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Swissprots Q9UMQ7 Q9Y3Q4
Accessions CCF23300 EAW77925 Q9Y3Q4 AJ132429 CAB42604 AJ238850 CAB52754 BC156298 AAI56299 BC172471 AAI72471 BM979827 BP291686 DQ854814 XM_011521148 XP_011519450 NM_005477 NP_005468
Function Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}; Multi- pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}.
Tissue Specificity Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953}.
Top Pathways cAMP signaling pathway

HCN4 CRISPR/Cas9 KO Plasmid (h) - sc-402293 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 HDR Plasmid (h) - sc-402293-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 Double Nickase Plasmid (h) - sc-402293-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 Double Nickase Plasmid (h2) - sc-402293-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 CRISPR Activation Plasmid (h) - sc-402293-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 CRISPR Activation Plasmid (h2) - sc-402293-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 Lentiviral Activation Particles (h) - sc-402293-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 Lentiviral Activation Particles (h2) - sc-402293-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HCN4 siRNA (h) - sc-42473 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HCN4 shRNA Plasmid (h) - sc-42473-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HCN4 shRNA (h) Lentiviral Particles - sc-42473-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2295 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2295 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06841 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06841

HCN4 siRNA (Human) - CRH6748 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCN4 RNAi - H00010021-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HCN4 - MBS8215694 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HCN4 (NM_005477.2) - SHH310857 from Creative biogene

Category siRNA
Species Reactivities Human

Human HCN4 siRNA - orb267250 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCN4 shRNA Plasmid (Human) - CHH6748 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HCN4 miRNA 3'UTR clone - MiUTR4H-TG11414 from Creative biogene

Species Reactivities Human
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