| Gene Symbol |
BECN1
|
| Entrez Gene |
8678
|
| Alt Symbol |
ATG6, VPS30, beclin1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beclin 1, autophagy related
|
| Other Description |
ATG6 autophagy related 6 homolog|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)|beclin-1|coiled-coil myosin-like BCL2-interacting protein
|
| Swissprots |
Q14457 Q9UNA8 O75595 B2R6N7
|
| Accessions |
EAW60888 EAW60889 EAW60890 Q14457 AF077301 AAC68653 AF139131 AAD27650 AK223411 BAD97131 AK298619 BAG60798 AK299616 BAG61544 AK312651 BAG35534 BC010276 AAH10276 BI496049 BX647788 DC296896 DQ891633 ABM82559 DQ894823 ABM85749 KC776730 AHF22836 L38932 AAB59573 XM_005257758 XP_005257815 XM_005257759 XP_005257816 XM_005257760 XP_005257817 XM_011525421 XP_011523723 NM_003766 NP_003757
|
| Function |
Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:9765397}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:O88597}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Regulation of autophagy
|
