BECN1

Gene Symbol	BECN1
Entrez Gene	8678
Alt Symbol	ATG6, VPS30, beclin1
Species	Human
Gene Type	protein-coding
Description	beclin 1, autophagy related
Other Description	ATG6 autophagy related 6 homolog|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)|beclin-1|coiled-coil myosin-like BCL2-interacting protein
Swissprots	Q14457 Q9UNA8 O75595 B2R6N7
Accessions	EAW60888 EAW60889 EAW60890 Q14457 AF077301 AAC68653 AF139131 AAD27650 AK223411 BAD97131 AK298619 BAG60798 AK299616 BAG61544 AK312651 BAG35534 BC010276 AAH10276 BI496049 BX647788 DC296896 DQ891633 ABM82559 DQ894823 ABM85749 KC776730 AHF22836 L38932 AAB59573 XM_005257758 XP_005257815 XM_005257759 XP_005257816 XM_005257760 XP_005257817 XM_011525421 XP_011523723 NM_003766 NP_003757
Function	Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:9765397}.
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:O88597}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.
Tissue Specificity	Ubiquitous.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Beclin 1 peptide - ab39729 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Beclin 1 full length protein - ab131770 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Beclin 1 full length protein - ab137161 from Abcam Category Protein Prices $345.00 Sizes 20 µg Source E. coli Species Human

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E2713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E2959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E5660 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E5661 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E30178 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E30177 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E21544 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E21445 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BECN1 / Beclin-1 Antibody Blocking Peptide - LS-E9702 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Beclin 1 Blocking Peptide - NB500-249PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Beclin 1 Partial Recombinant Protein - H00008678-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Recombinant Human Beclin 1 Protein - NBP2-22710 from Novus Biologicals Category Protein Prices $299.00 Sizes 20 µg Source E.coli Species Human

Beclin 1 Recombinant Protein - H00008678-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Beclin-1-Antibody-Blocking-peptide - BP13795a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BECN1-Antibody-N-term-T72-Blocking-peptide - BP14089a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Beclin-1-Antibody-Blocking-peptide - BP1818b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Beclin-1-Antibody-Blocking-peptide - BP1818a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Beclin1-BH3-Domain-Antibody-Blocking-Peptide - BP8653a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human BECN1 protein - orb167975 from Biorbyt Category Protein Prices $230.00, $442.00, $1,811.00 Sizes 2 μg, 10 μg, 100 μg Source E. coli Species Human

Beclin 1 Blocking Peptide - 33R-10861 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BECN1 Blocking Peptide - 33R-6603 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BECN1 Blocking Peptide - 33R-2611 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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