BECN1

Gene Symbol	BECN1
Entrez Gene	8678
Alt Symbol	ATG6, VPS30, beclin1
Species	Human
Gene Type	protein-coding
Description	beclin 1, autophagy related
Other Description	ATG6 autophagy related 6 homolog|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)|beclin-1|coiled-coil myosin-like BCL2-interacting protein
Swissprots	Q14457 Q9UNA8 O75595 B2R6N7
Accessions	EAW60888 EAW60889 EAW60890 Q14457 AF077301 AAC68653 AF139131 AAD27650 AK223411 BAD97131 AK298619 BAG60798 AK299616 BAG61544 AK312651 BAG35534 BC010276 AAH10276 BI496049 BX647788 DC296896 DQ891633 ABM82559 DQ894823 ABM85749 KC776730 AHF22836 L38932 AAB59573 XM_005257758 XP_005257815 XM_005257759 XP_005257816 XM_005257760 XP_005257817 XM_011525421 XP_011523723 NM_003766 NP_003757
Function	Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:9765397}.
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:O88597}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.
Tissue Specificity	Ubiquitous.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Beclin-1 siRNA I - 6222 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Beclin-1 siRNA II - 6246 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

BECN1 CRISPR/Cas9 KO Plasmid (h) - sc-400139 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 HDR Plasmid (h) - sc-400139-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 Double Nickase Plasmid (h) - sc-400139-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 Double Nickase Plasmid (h2) - sc-400139-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 CRISPR Activation Plasmid (h) - sc-400139-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 CRISPR Activation Plasmid (h2) - sc-400139-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 Lentiviral Activation Particles (h) - sc-400139-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 Lentiviral Activation Particles (h2) - sc-400139-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BECN1 siRNA (h) - sc-29797 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BECN1 shRNA Plasmid (h) - sc-29797-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BECN1 shRNA (h) Lentiviral Particles - sc-29797-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BECN1 siRNA (h2) - sc-44286 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BECN1 shRNA Plasmid (h2) - sc-44286-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BECN1 shRNA (h2) Lentiviral Particles - sc-44286-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU061741 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2175 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2175 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05132 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05132

BECN1 siRNA (Human) - CRH5712 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BECN1 - MBS8223433 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BECN1 (NM_003766.3) - SHH246274 from Creative biogene Category siRNA Species Reactivities Human

Human BECN1 siRNA - orb266214 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BECN1 shRNA Plasmid (Human) - CHH5712 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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