Gene Symbol | ZFP36L2 |
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Entrez Gene | 678 |
Alt Symbol | BRF2, ERF-2, ERF2, RNF162C, TIS11D |
Species | Human |
Gene Type | protein-coding |
Description | ZFP36 ring finger protein-like 2 |
Other Description | EGF-response factor 2|ZFP36-like 2|butyrate response factor 2|zinc finger protein 36, C3H type-like 1|zinc finger protein 36, C3H type-like 2|zinc finger protein 36, C3H1 type-like 2|zinc finger protein, C3H type, 36-like 2 |
Swissprots | Q9BSJ3 Q53TB4 P47974 |
Accessions | AAA91778 AAY14992 EAX00305 EAX00306 P47974 BC005010 AAH05010 BC020369 BE222042 BI489986 BI548620 DQ893399 ABM84325 DQ896782 ABM87781 N67537 X78992 CAA55592 NM_006887 NP_008818 |
Function | mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:14981510}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}. |
TIS11D (A-3) - sc-365908 from Santa Cruz Biotechnology
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TIS11D (P-16) - sc-79154 from Santa Cruz Biotechnology
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TIS11D (Y-15) - sc-79155 from Santa Cruz Biotechnology
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Anti-TIS11D antibody - ab84592 from Abcam
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Anti-TIS11D antibody - ab173361 from Abcam
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Anti-TIS11D antibody - ab70775 from Abcam
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Anti-ZFP36L2 Antibody (aa36-85) IHC-plus™ - LS-B6682 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (His243) - LS-C192010 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, AP) - LS-C273995 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, APC) - LS-C273996 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (N-Terminus) - LS-C31176 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, Biotin) - LS-C273997 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, FITC) - LS-C273998 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, Azide-free, HRP) - LS-C273999 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193, PE) - LS-C274001 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa165-193) - LS-C326489 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa207-256) - LS-C118903 from LifeSpan Bioscience
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Anti-ZFP36L2 Antibody (aa166-193) - LS-C157404 from LifeSpan Bioscience
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TIS11D Antibody - NBP1-92510 from Novus Biologicals
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BRF2 Polyclonal Antibody - bs-6882R from Bioss
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Anti-ZFP36L2 antibody produced in rabbit - SAB2102767 from Sigma-Aldrich
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Anti-ZFP36L2 antibody produced in rabbit - HPA047428 from Sigma-Aldrich
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Anti-ZFP36L2 antibody produced in rabbit - AV38875 from Sigma-Aldrich
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Anti-TISD antibody produced in rabbit - SAB4502883 from Sigma-Aldrich
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ZFP36L2 antibody - N-terminal region (ARP33383_P050) - ARP33383_P050 from Aviva Systems Biology
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