| Gene Symbol |
ZFP36L2
|
| Entrez Gene |
678
|
| Alt Symbol |
BRF2, ERF-2, ERF2, RNF162C, TIS11D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ZFP36 ring finger protein-like 2
|
| Other Description |
EGF-response factor 2|ZFP36-like 2|butyrate response factor 2|zinc finger protein 36, C3H type-like 1|zinc finger protein 36, C3H type-like 2|zinc finger protein 36, C3H1 type-like 2|zinc finger protein, C3H type, 36-like 2
|
| Swissprots |
Q9BSJ3 Q53TB4 P47974
|
| Accessions |
AAA91778 AAY14992 EAX00305 EAX00306 P47974 BC005010 AAH05010 BC020369 BE222042 BI489986 BI548620 DQ893399 ABM84325 DQ896782 ABM87781 N67537 X78992 CAA55592 NM_006887 NP_008818
|
| Function |
mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:14981510}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
|