PDCD6IP

Gene Symbol	PDCD6IP
Entrez Gene	10015
Alt Symbol	AIP1, ALIX, DRIP4, HP95
Species	Human
Gene Type	protein-coding
Description	programmed cell death 6 interacting protein
Other Description	ALG-2 interacting protein 1|ALG-2-interacting protein X|PDCD6-interacting protein|apoptosis-linked gene 2-interacting protein X|dopamine receptor interacting protein 4|programmed cell death 6-interacting protein
Swissprots	E9PFU1 Q9P2H2 Q9NUN0 C5MQH7 Q9UKL5 Q9BX86 Q6NUS1 Q8WUM4
Accessions	EAW64468 EAW64469 Q8WUM4 AB037796 BAA92613 AF151793 AAF08220 AF250394 AAQ14260 AF349951 AAK20398 AI346371 AK002122 BAA92092 AK295042 BAG58093 AK298727 BAH12857 AL695629 BC020066 AAH20066 BC068454 AAH68454 BI492166 BI562417 BM669193 BQ024882 BQ895877 BT007367 AAP36031 BU165197 BU194828 CR739098 DA149360 DA652213 GQ131806 ACS12984 XM_011533252 XP_011531554 XM_011533253 XP_011531555 NM_001162429 NP_001155901 NM_001256192 NP_001243121 NM_013374 NP_037506 NR_027867
Function	Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cel
Subcellular Location	Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALIX full length protein - ab132534 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ALIX peptide - ab88953 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

Human ALIX peptide - ab89369 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

Human ALIX protein fragment - ab93658 from Abcam Category Protein Prices $188.00, $692.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Recombinant Human Alix Protein - NBP1-40401 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

Alix Partial Recombinant Protein - H00010015-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Alix Recombinant Protein - H00010015-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDCD6IP Protein (OPPA02116) - OPPA02116 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Programmed Cell Death Interacting protein - orb81265 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 25 μg Source E.coli Species Human

Alix protein (His tag) - 80R-1259 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

ALIX / PDCD6IP (1-392, His-tag) - AR09381PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

ALIX / PDCD6IP (1-392, His-tag) - AR09381PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

ALIX / PDCD6IP - H00010015-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ALIX / PDCD6IP - H00010015-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ALIX / PDCD6IP - H00010015-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ALIX / PDCD6IP - H00010015-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Alix, 1-392aa, Human, His tag, E.coli - 01-1784 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ALIX; AIP1 fusion protein - ag3074 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Programmed Cell Death 6 Interacting Protein - BP002401-PRO-792 from Syd Labs Category Protein Prices $160.00, $2,250.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

Alix, 1-392aa, Recombinant Protein - GWB-P1556I from Genway Biotech Category Protein Prices $260.00, $780.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Programmed Cell Death 6 Interacting Protein - GWB-2CBE6C from Genway Biotech Category Protein Prices $75.00, $165.00, $2,685.00 Sizes 5 μg, 20 μg, 1000 μg Species Human

Recombinant Human PDCD6IP, His-tagged - PDCD6IP-1938H from Creative Biomart Category Protein Source E.coli.

Recombinant Human PDCD6IP, His-tagged - PDCD6IP-27933TH from Creative Biomart Category Protein Source E. coli

Recombinant Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) - RPB247Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) - RPB247Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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