PDCD6IP
| Gene Symbol | PDCD6IP |
|---|---|
| Entrez Gene | 10015 |
| Alt Symbol | AIP1, ALIX, DRIP4, HP95 |
| Species | Human |
| Gene Type | protein-coding |
| Description | programmed cell death 6 interacting protein |
| Other Description | ALG-2 interacting protein 1|ALG-2-interacting protein X|PDCD6-interacting protein|apoptosis-linked gene 2-interacting protein X|dopamine receptor interacting protein 4|programmed cell death 6-interacting protein |
| Swissprots | E9PFU1 Q9P2H2 Q9NUN0 C5MQH7 Q9UKL5 Q9BX86 Q6NUS1 Q8WUM4 |
| Accessions | EAW64468 EAW64469 Q8WUM4 AB037796 BAA92613 AF151793 AAF08220 AF250394 AAQ14260 AF349951 AAK20398 AI346371 AK002122 BAA92092 AK295042 BAG58093 AK298727 BAH12857 AL695629 BC020066 AAH20066 BC068454 AAH68454 BI492166 BI562417 BM669193 BQ024882 BQ895877 BT007367 AAP36031 BU165197 BU194828 CR739098 DA149360 DA652213 GQ131806 ACS12984 XM_011533252 XP_011531554 XM_011533253 XP_011531555 NM_001162429 NP_001155901 NM_001256192 NP_001243121 NM_013374 NP_037506 NR_027867 |
| Function | Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cel |
| Subcellular Location | Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells. |
| Top Pathways | Endocytosis |
Alix CRISPR/Cas9 KO Plasmid (h) - sc-400350 from Santa Cruz Biotechnology
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Alix HDR Plasmid (h) - sc-400350-HDR from Santa Cruz Biotechnology
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Alix Double Nickase Plasmid (h) - sc-400350-NIC from Santa Cruz Biotechnology
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Alix Double Nickase Plasmid (h2) - sc-400350-NIC-2 from Santa Cruz Biotechnology
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Alix CRISPR Activation Plasmid (h) - sc-400350-ACT from Santa Cruz Biotechnology
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Alix CRISPR Activation Plasmid (h2) - sc-400350-ACT-2 from Santa Cruz Biotechnology
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Alix Lentiviral Activation Particles (h) - sc-400350-LAC from Santa Cruz Biotechnology
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Alix Lentiviral Activation Particles (h2) - sc-400350-LAC-2 from Santa Cruz Biotechnology
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Alix siRNA (h) - sc-60149 from Santa Cruz Biotechnology
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Alix shRNA Plasmid (h) - sc-60149-SH from Santa Cruz Biotechnology
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Alix shRNA (h) Lentiviral Particles - sc-60149-V from Santa Cruz Biotechnology
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Alix RNAi - H00010015-R01 from Novus Biologicals
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MISSION® esiRNA - EHU024581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16522 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16522 from Sigma-Aldrich
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PDCD6IP siRNA (Human) - CRH6742 from Cohesion Biosciences
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shRNA set against Human PDCD6IP (NM_013374.5) - SHH372248 from Creative biogene
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Human PDCD6IP siRNA - orb267244 from Biorbyt
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PDCD6IP shRNA Plasmid (Human) - CHH6742 from Cohesion Biosciences
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