FRK

Gene Symbol FRK
Entrez Gene 2444
Alt Symbol GTK, PTK5, RAK
Species Human
Gene Type protein-coding
Description fyn-related Src family tyrosine kinase
Other Description PTK5 protein tyrosine kinase 5|fyn-related kinase|nuclear tyrosine protein kinase RAK|protein-tyrosine kinase 5|tyrosine-protein kinase FRK
Swissprots P42685 Q9NTR5 B4DY49 Q13128
Accessions EAW48241 P42685 AK302264 BAG63611 AK313314 BAG36119 BC012916 AAH12916 DQ894643 ABM85569 U00803 AAA18284 U22322 AAC50116 XM_005266880 XP_005266937 XM_005266881 XP_005266938 XM_005266882 XP_005266939 XM_011535653 XP_011533955 XM_011535654 XP_011533956 XM_011535655 XP_011533957 XM_011535656 XP_011533958 NM_002031 NP_002022
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Tissue Specificity Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. {ECO:0000269|PubMed:7696183}.

Rak (H-12) - sc-166478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rak (H-12): sc-166478. Western blot analysis of Rak expression in non-transfected: sc-117752 (A) and human Rak transfected: sc-113821 (B) 293T whole cell lysates.

Rak (H-46) - sc-366182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Rak (C-20) - sc-6377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rak (C-20): sc-6377. Western blot analysis of Rak expression in non-transfected: sc-117752 (A) and human Rak transfected: sc-113821 (B) 293T whole cell lysates.

Rak (M-20) - sc-6378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FRK antibody - ab64914 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab64914, at a 1/50 dilution, staining Human FRK in paraffin embedded breast carcinoma tissue, by Immunohistochemistry, with (+) or without (-) immunising peptide.

Anti-FRK antibody - ab154032 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FRK antibody (ab154032) at 1/500 dilution + Molt4 whole cell lysate at 30 µg

Anti-FRK antibody - ab176873 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FRK antibody (ab176873) at 1/500 dilution + K562 cell lysate

Anti-FRK antibody - ab87201 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FRK antibody (ab87201) at 1 µg/ml (in 5% skim milk / PBS buffer) + Transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-FRK antibody - ab123732 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-FRK antibody (ab123732) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

Anti-FRK antibody [1A8H2C12] - ab70426 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1A8H2C12
Anti-FRK antibody [1A8H2C12] (ab70426) at 1/500 dilution + Truncated FRK recombinant protein with His tag

Anti-FRK antibody [4E1] - ab91623 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E1
Anti-FRK antibody [4E1] (ab91623) at 1/500 dilution + K562 cell lysate

Anti-FRK antibody [5F3] - ab114006 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5F3
ab114006 at 1/100 staining FRK in COS7 cells transiently transfected by pCMV6-ENTRY FRK and analyzed by immunofluorescence.

Anti-FRK Antibody (clone 6D2) - LS-C114623 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6D2
IHC of paraffin-embedded Ovary tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).

Anti-FRK Antibody (clone 1A8H2C12) IHC-plus™ - LS-B4095 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1A8H2C12
Anti-FRK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4095 dilution 1:200.

Anti-FRK Antibody (aa1-107) - LS-C36374 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-FRK Antibody (clone 4E1) - LS-C108818 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E1
Western blot using FRK mouse monoclonal antibody against K562 cell lysate (1).

Anti-FRK Antibody (aa492-505) - LS-C129164 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FRK Antibody (aa35-84) - LS-C102562 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FRK antibody LS-C102562 Western blot of Transfected 293T cell lysate.

Anti-FRK Antibody (aa218-267) - LS-C81887 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-FRK Antibody (aa464-491, AP) - LS-C257401 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FRK Antibody (aa464-491, APC) - LS-C257402 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FRK Antibody (aa464-491, Biotin) - LS-C257403 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FRK Antibody (aa464-491, FITC) - LS-C257404 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FRK Antibody (aa464-491, Azide-free, HRP) - LS-C257405 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FRK Antibody (aa464-491, PE) - LS-C257409 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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