FRK

Gene Symbol	FRK
Entrez Gene	2444
Alt Symbol	GTK, PTK5, RAK
Species	Human
Gene Type	protein-coding
Description	fyn-related Src family tyrosine kinase
Other Description	PTK5 protein tyrosine kinase 5|fyn-related kinase|nuclear tyrosine protein kinase RAK|protein-tyrosine kinase 5|tyrosine-protein kinase FRK
Swissprots	P42685 Q9NTR5 B4DY49 Q13128
Accessions	EAW48241 P42685 AK302264 BAG63611 AK313314 BAG36119 BC012916 AAH12916 DQ894643 ABM85569 U00803 AAA18284 U22322 AAC50116 XM_005266880 XP_005266937 XM_005266881 XP_005266938 XM_005266882 XP_005266939 XM_011535653 XP_011533955 XM_011535654 XP_011533956 XM_011535655 XP_011533957 XM_011535656 XP_011533958 NM_002031 NP_002022
Function	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Tissue Specificity	Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. {ECO:0000269|PubMed:7696183}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rak CRISPR/Cas9 KO Plasmid (h) - sc-405590 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak HDR Plasmid (h) - sc-405590-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak Double Nickase Plasmid (h) - sc-405590-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak Double Nickase Plasmid (h2) - sc-405590-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak CRISPR Activation Plasmid (h) - sc-405590-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak CRISPR Activation Plasmid (h2) - sc-405590-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak Lentiviral Activation Particles (h) - sc-405590-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak Lentiviral Activation Particles (h2) - sc-405590-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rak siRNA (h) - sc-39231 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rak shRNA Plasmid (h) - sc-39231-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rak shRNA (h) Lentiviral Particles - sc-39231-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU037571 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0819 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0820 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0818 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN8941 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8941 from Sigma-Aldrich Category ZFN Kit

MISSION® 3′UTR Lenti GoClone™ - HUTR06998 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06998

FRK siRNA (Human) - CRH1652 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Frk RNAi - H00002444-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FRK - MBS8209614 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FRK (NM_002031.2) - SHH297093 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human FRK(NM_002031.2) - SHH068087 from Creative biogene Category siRNA Species Reactivities Human

Human FRK siRNA - orb262154 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FRK shRNA Plasmid (Human) - CHH1652 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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