| Gene Symbol |
FRK
|
| Entrez Gene |
2444
|
| Alt Symbol |
GTK, PTK5, RAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fyn-related Src family tyrosine kinase
|
| Other Description |
PTK5 protein tyrosine kinase 5|fyn-related kinase|nuclear tyrosine protein kinase RAK|protein-tyrosine kinase 5|tyrosine-protein kinase FRK
|
| Swissprots |
P42685 Q9NTR5 B4DY49 Q13128
|
| Accessions |
EAW48241 P42685 AK302264 BAG63611 AK313314 BAG36119 BC012916 AAH12916 DQ894643 ABM85569 U00803 AAA18284 U22322 AAC50116 XM_005266880 XP_005266937 XM_005266881 XP_005266938 XM_005266882 XP_005266939 XM_011535653 XP_011533955 XM_011535654 XP_011533956 XM_011535655 XP_011533957 XM_011535656 XP_011533958 NM_002031 NP_002022
|
| Function |
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
|
| Tissue Specificity |
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. {ECO:0000269|PubMed:7696183}.
|