Gene Symbol |
TAPBPL
|
Entrez Gene |
55080
|
Alt Symbol |
TAPBP-R, TAPBPR
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
TAP binding protein-like
|
Other Description |
TAP binding protein related|TAP-binding protein-like|TAP-binding protein-related protein|TAPASIN-R|tapasin-like|tapasin-related protein
|
Swissprots |
Q9NWB8 Q9BX59
|
Accessions |
CAI93432 EAW88797 EAW88798 EAW88799 Q9BX59 AI184901 AI273155 AK001005 BAA91465 AK002056 BAB41077 AK098035 AK222956 BAD96676 AK223163 BAD96883 BC015017 AAH15017 CR997450 DB054664 HQ258015 ADR82769 XM_005253699 XP_005253756 XM_005253700 XP_005253757 XM_005253701 XP_005253758 XM_005253702 XP_005253759 XM_005253703 XP_005253760 XM_011520966 XP_011519268 XR_429016 NM_018009 NP_060479
|
Function |
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}.
|
Subcellular Location |
Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface.
|