Gene Symbol | TAPBPL |
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Entrez Gene | 55080 |
Alt Symbol | TAPBP-R, TAPBPR |
Species | Human |
Gene Type | protein-coding |
Description | TAP binding protein-like |
Other Description | TAP binding protein related|TAP-binding protein-like|TAP-binding protein-related protein|TAPASIN-R|tapasin-like|tapasin-related protein |
Swissprots | Q9NWB8 Q9BX59 |
Accessions | CAI93432 EAW88797 EAW88798 EAW88799 Q9BX59 AI184901 AI273155 AK001005 BAA91465 AK002056 BAB41077 AK098035 AK222956 BAD96676 AK223163 BAD96883 BC015017 AAH15017 CR997450 DB054664 HQ258015 ADR82769 XM_005253699 XP_005253756 XM_005253700 XP_005253757 XM_005253701 XP_005253758 XM_005253702 XP_005253759 XM_005253703 XP_005253760 XM_011520966 XP_011519268 XR_429016 NM_018009 NP_060479 |
Function | Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. |
Subcellular Location | Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface. |
TAPBPL CRISPR/Cas9 KO Plasmid (h) - sc-409990 from Santa Cruz Biotechnology
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TAPBPL HDR Plasmid (h) - sc-409990-HDR from Santa Cruz Biotechnology
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TAPBPL Double Nickase Plasmid (h) - sc-409990-NIC from Santa Cruz Biotechnology
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TAPBPL Double Nickase Plasmid (h2) - sc-409990-NIC-2 from Santa Cruz Biotechnology
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TAPBPL CRISPR Activation Plasmid (h) - sc-409990-ACT from Santa Cruz Biotechnology
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TAPBPL CRISPR Activation Plasmid (h2) - sc-409990-ACT-2 from Santa Cruz Biotechnology
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TAPBPL Lentiviral Activation Particles (h) - sc-409990-LAC from Santa Cruz Biotechnology
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TAPBPL Lentiviral Activation Particles (h2) - sc-409990-LAC-2 from Santa Cruz Biotechnology
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TAPBPL siRNA (h) - sc-96046 from Santa Cruz Biotechnology
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TAPBPL shRNA Plasmid (h) - sc-96046-SH from Santa Cruz Biotechnology
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TAPBPL shRNA (h) Lentiviral Particles - sc-96046-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21000 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21000 from Sigma-Aldrich
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TAPBPL siRNA (Human) - CRJ0452 from Cohesion Biosciences
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Tapasin Related Protein RNAi - H00055080-R01 from Novus Biologicals
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TAPBPL - MBS8240253 from MyBioSource
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shRNA set against Human TAPBPL (NM_018009.4) - SHH423048 from Creative biogene
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shRNA set against Mouse Tap1(NM_013683.1) - SHL055992 from Creative biogene
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TAPBPL shRNA Plasmid (Human) - CHJ0452 from Cohesion Biosciences
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TAPBPL miRNA 3'UTR clone - MiUTR1H-10178 from Creative biogene
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