CRK

Gene Symbol CRK
Entrez Gene 1398
Alt Symbol CRKII, p38
Species Human
Gene Type protein-coding
Description v-crk avian sarcoma virus CT10 oncogene homolog
Other Description adapter molecule crk|proto-oncogene c-Crk
Swissprots Q96HJ0 A8MWE8 Q96GA9 D3DTH6 B0LPE8 P46108
Accessions AAB28213 ABY87527 AGC09588 EAW90621 EAW90622 EAW90623 EAW90624 EAW90625 EAW90626 P46108 AK095449 AK291060 BAF83749 AU125411 BC001718 AAH01718 BC008506 AAH08506 BC009837 AAH09837 BT007277 AAP35941 D10656 BAA01505 DQ891147 ABM82073 DQ894327 ABM85253 NM_005206 NP_005197 NM_016823 NP_058431
Function The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, MicroRNAs in cancer, Focal adhesion

Phospho-CrkII (Tyr221) Antibody - 3491 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 cells, untreated or calf intestinal phosphatase (CIP)-treated, using Phospho-CrkII (Tyr221) Antibody.

CrkII Antibody - 3492 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HepG2 cells (human hepatocellular carcinoma) and NIH/3T3 cells (mouse fibroblasts), using CrkII Antibody.

Crk II (B-4) - sc-390132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Crk II (B-4): sc-390132. Western blot analysis of Crk II expression in non-transfected: sc-110760 (A) and human Crk II transfected: sc-110474 (B) 293 whole cell lysates.

Crk I/II (D-6) - sc-393160 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Crk I/II (D-6): sc-393160. Western blot analysis of Crk II expression in non-transfected: sc-110760 (A) and human Crk II transfected: sc-110474 (B) 293 whole cell lysates.

Crk I/II (E-14) - sc-23775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Crk I/II (E-14): sc-23775. Western blot analysis of Crk I/II expression in HeLa whole cell lysate.

Crk I/II (S-20) - sc-17989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Crk I/II (S-20): sc-17989. Western blot analysis of Crk I/II expression in non-transfected: sc-110760 (A) and human Crk I/II transfected: sc-110474 (B) 293 whole cell lysates.

Crk II (C-18) - sc-289 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Crk II (C-18): sc-289. Western blot analysis of Crk II expression in HeLa (A), K-562 (B), NIH/3T3 (C) and Rat 1 Rin (D) whole cell lysates.

Crk II (H-53) - sc-9004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Crk II (H-53): sc-9004. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing membrane staining of hepatocytes and bile duct cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Crk II (2210C1a) - sc-81234 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Crk II (2210C1a): sc-81234. Western blot analysis of Crk II expression in non-transfected: sc-110760 (A) and human Crk II transfected: sc-110474 (B) 293 whole cell lysates.

p-Crk II (Ser 41) - sc-130186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Crk II (Ser 41): sc-130186. Western blot analysis of Crk II phosphorylation in non-transfected: sc-117752 (A) and mouse Crk II transfected: sc-125171 (B) 293T whole cell lysates.

Anti-Adapter molecule crk (phospho Y221) antibody - ab195846 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Adapter molecule crk (phospho Y221) antibody (ab195846) at 1/500 dilutionLane 1 : COS7 whole cell lysates with antigen-specific peptideLane 2 : COS7 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Crk p38 (phospho Y221) antibody - ab51222 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Crk p38 (phospho Y221) antibody (ab51222) at 1/300 dilutionLane 1 : Extracts of cos7 cells treated with phosphopeptideLane 2 : Extracts of cos7 cells

Anti-Crk p38 (phospho Y221) antibody [EPR269Y] - ab76227 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR269Y
All lanes : Anti-Crk p38 (phospho Y221) antibody [EPR269Y] (ab76227) at 1/2000 dilutionLane 1 : K562 cell lysateLane 2 : K562 cell lysate treated with APLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Crk p38 antibody - ab51211 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Crk p38 antibody (ab51211)Lane 1 : Extracts from cos7 cells with no immunising peptideLane 2 : Extracts from cos7 cells with immunising peptide

Anti-Crk p38 antibody - ab122949 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Crk p38 antibody (ab122949) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

Anti-Crk p38 antibody [2210C1a] - ab51347 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2210C1a
Anti-Crk p38 antibody [2210C1a] (ab51347) + Recombinant Crk p38

Anti-Crk p38 antibody [3G11C1] - ab119916 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G11C1
Anti-Crk p38 antibody [3G11C1] (ab119916) at 1/500 dilution + Recombinant Human Crk p38 protein

Anti-Crk p38 antibody [3H7-E5-H8] - ab131186 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H7-E5-H8
All lanes : Anti-Crk p38 antibody [3H7-E5-H8] (ab131186) at 1/1000 dilutionLane 1 : LNCaP cell lysateLane 2 : A431 cell lysateLane 3 : MCF7 cell lysateLane 4 : HL1080 cell lysate

Anti-Crk p38 antibody [EP242Y] - ab45136 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP242Y
Anti-Crk p38 antibody [EP242Y] (ab45136) at 1/10000 dilution + HepG2 cell lysate at 10 µgSecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Crk p38 antibody [EPR4984(2)] - ab133581 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4984(2)
ab133581, at a 1/100, staining Crk p38 in permeabilized HepG2 cells using flow cytometry analysis (Red). Green curve corresponds to a control Rabbit IgG antibody (negative control).

Anti-CRK Antibody (phospho-Tyr221) - LS-C36017 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRK Antibody (aa2-246) - LS-C343963 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Crk p38 antibody IHC-paraffin: Rat Brain Tissue.

Anti-CRK Antibody (clone 3G11C1) - LS-C169406 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3G11C1
IHC of paraffin-embedded rectum cancer tissues using CRK mouse monoclonal antibody with DAB staining.

Anti-CRK Antibody (clone 3G11E8) - LS-C169407 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3G11E8
IHC of paraffin-embedded intima cancer tissues using CRK mouse monoclonal antibody with DAB staining.

Anti-CRK Antibody - LS-C79926 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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