CRK

Gene Symbol	CRK
Entrez Gene	1398
Alt Symbol	CRKII, p38
Species	Human
Gene Type	protein-coding
Description	v-crk avian sarcoma virus CT10 oncogene homolog
Other Description	adapter molecule crk|proto-oncogene c-Crk
Swissprots	Q96HJ0 A8MWE8 Q96GA9 D3DTH6 B0LPE8 P46108
Accessions	AAB28213 ABY87527 AGC09588 EAW90621 EAW90622 EAW90623 EAW90624 EAW90625 EAW90626 P46108 AK095449 AK291060 BAF83749 AU125411 BC001718 AAH01718 BC008506 AAH08506 BC009837 AAH09837 BT007277 AAP35941 D10656 BAA01505 DQ891147 ABM82073 DQ894327 ABM85253 NM_005206 NP_005197 NM_016823 NP_058431
Function	The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
Top Pathways	Rap1 signaling pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, MicroRNAs in cancer, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Crk p38 full length protein - ab101046 from Abcam Category Protein Source E. coli Species Human

Mouse Crk p38 peptide - ab95851 from Abcam Category Peptide

CRK Antibody Blocking Peptide - LS-E10583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRK Antibody Blocking Peptide - LS-E7339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Crk Protein - H00001398-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Crk Partial Recombinant Protein - H00001398-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Crk Protein - NBP1-50852 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

Crk Peptide - P1457 from Novus Biologicals Category Peptide Species Human

Phospho-CRKS41-Antibody-Blocking-peptide - BP3304a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

CRK Protein Lysate (APL10281) - APL10281 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CRK Protein Lysate (APL10439) - APL10439 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CRK Protein (OPPA02594) - OPPA02594 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human CRK protein - orb168155 from Biorbyt Category Protein Prices $170.00, $289.00, $1,046.00 Sizes 1 μg, 5 μg, 50 μg Species Human

CRK peptide - orb219048 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CRK protein (His tag) - 80R-1527 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

CRK Blocking Peptide - abx062079 from Abbexa Category Peptide Species Human, Mouse, Rat

CRK (1-204, His-tag) - AR09705PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

CRK (1-204, His-tag) - AR09705PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

CRK - H00001398-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CRK - H00001398-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CRK - H00001398-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CRK - H00001398-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CRK, 1-204aa, Human, His tag, E.coli - 01-2394 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

CRK fusion protein - Ag10016 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CRK fusion protein - ag1420 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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