| Gene Symbol | CRK |
|---|---|
| Entrez Gene | 1398 |
| Alt Symbol | CRKII, p38 |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-crk avian sarcoma virus CT10 oncogene homolog |
| Other Description | adapter molecule crk|proto-oncogene c-Crk |
| Swissprots | Q96HJ0 A8MWE8 Q96GA9 D3DTH6 B0LPE8 P46108 |
| Accessions | AAB28213 ABY87527 AGC09588 EAW90621 EAW90622 EAW90623 EAW90624 EAW90625 EAW90626 P46108 AK095449 AK291060 BAF83749 AU125411 BC001718 AAH01718 BC008506 AAH08506 BC009837 AAH09837 BT007277 AAP35941 D10656 BAA01505 DQ891147 ABM82073 DQ894327 ABM85253 NM_005206 NP_005197 NM_016823 NP_058431 |
| Function | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}. |
| Top Pathways | Rap1 signaling pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, MicroRNAs in cancer, Focal adhesion |