CCDC8

Gene Symbol CCDC8
Entrez Gene 83987
Alt Symbol 3M3, PPP1R20, p90
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 8
Other Description coiled-coil domain-containing protein 8|protein phosphatase 1, regulatory subunit 20
Swissprots Q9H0W5 Q8TB26
Accessions EAW57418 Q9H0W5 AI301367 AK297668 BAG60030 AL136609 CAB66544 BC015648 BC025243 AAH25243 BG717344 BX096201 EU831718 ACE86552 JN703457 AET25567 NM_032040 NP_114429
Function Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:24793695}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24793695}.
Tissue Specificity Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver. {ECO:0000269|PubMed:21737058}.

CCDC8 (C-16) - sc-242376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CCDC8 (P-16) - sc-242375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CCDC8 (S-17) - sc-242374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCDC8 antibody - ab170233 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labeling CCDC8 with ab170233 at 1/50.

Anti-CCDC8 antibody - ab110874 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of CCDC8 by Western Blot of Immunprecipitate. anti-CCDC8 at 0.4µg/ml staining CCDC8 in 293T whole cell lysate immunoprecipitated using ab110874 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.

Anti-CCDC8 Antibody (aa390-418, AP) - LS-C233498 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418, Biotin) - LS-C233501 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418, FITC) - LS-C233502 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418, APC) - LS-C233500 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418, PE) - LS-C233503 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418, Azide-free, HRP) - LS-C249599 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa350-400) - LS-C289695 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa488-538) - LS-C289696 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa397-426) - LS-C320084 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 Antibody (aa390-418) - LS-C168436 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CCDC8 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

CCDC8 Antibody - NBP1-85085 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: CCDC8 Antibody [NBP1-85085] - Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

CCDC8 Antibody - NBP1-50021 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CCDC8 Antibody [NBP1-50021] - Detection of Human CCDC8 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from 293T (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and K562 (K; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-CCDC8 antibody used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. CCDC8 was also immunoprecipitated by rabbit anti-CCDC8 antibody which recognizes a downstream epitope. For blotting immunoprecipitated CCDC8, the ReliaBLOT (R) Reagents and Procedures were used. Detection: Chemiluminescence with exposure times of 10 seconds (A and B).

CCDC8 Antibody - NBP1-50022 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: CCDC8 Antibody [NBP1-50022] - Detection of Human CCDC8 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-CCDC8 antibody used for IP at 6 mcg/mg lysate. CCDC8 was also immunoprecipitated by rabbit anti-CCDC8 antibody which recognizes an upstream epitope. For blotting immunoprecipitated CCDC8 was used at 0.4 mcg/ml, and the ReliaBLOT Reagents and Procedures were incorporated. Detection: Chemiluminescence with an exposure time of 10 seconds.

CCDC8 Antibody - H00083987-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CCDC8 Antibody [H00083987-B01P] - Analysis of CCDC8 expression in rat brain.

CCDC8 Polyclonal Antibody - bs-8138R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC8 antibody produced in mouse - SAB1409877 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CCDC8: <B>Cat. No. SAB1409877</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~59.4 kDa using CCDC8 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CCDC8 antibody produced in rabbit - HPA041993 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CCDC8: <B>Cat. No. HPA041993</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in renal tubules.

ANTI-CCDC8 (C-TERM) antibody produced in rabbit - SAB1303398 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CCDC8 (C-term): <B>Cat. No. SAB1303398 </B>: CCDC8 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35 μg/lane).

CCDC8 Antibody - C-terminal region (OAAB00571) - OAAB00571 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CCDC8-Antibody-C-term - AP10554b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CCDC8 Antibody (C-term) (Cat. #AP10554b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CCDC8 antibody detected the CCDC8 protein (arrow).
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