| Gene Symbol |
CCDC8
|
| Entrez Gene |
83987
|
| Alt Symbol |
3M3, PPP1R20, p90
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil domain containing 8
|
| Other Description |
coiled-coil domain-containing protein 8|protein phosphatase 1, regulatory subunit 20
|
| Swissprots |
Q9H0W5 Q8TB26
|
| Accessions |
EAW57418 Q9H0W5 AI301367 AK297668 BAG60030 AL136609 CAB66544 BC015648 BC025243 AAH25243 BG717344 BX096201 EU831718 ACE86552 JN703457 AET25567 NM_032040 NP_114429
|
| Function |
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24793695}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24793695}.
|
| Tissue Specificity |
Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver. {ECO:0000269|PubMed:21737058}.
|
![Western Blot: CCDC8 Overexpression Lysate (Adult Normal) [NBL1-08824] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCDC8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7808_CCDC8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08824-img0002.jpg)