| Gene Symbol |
ACOT4
|
| Entrez Gene |
122970
|
| Alt Symbol |
PTE-Ib, PTE1B, PTE2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA thioesterase 4
|
| Other Description |
PTE-2b|acyl-coenzyme A thioesterase 4|peroxisomal acyl coenzyme A thioester hydrolase Ib|peroxisomal acyl-CoA thioesterase 2B|peroxisomal long-chain acyl-CoA thioesterase Ib
|
| Swissprots |
Q86TX1 Q96N88 Q17RF4 Q5BKT6 Q8N9L9 Q86TX0
|
| Accessions |
EAW81120 EAW81121 Q8N9L9 AK055797 BAB71017 AK094223 BAC04313 BC031799 AAH31799 BC090945 AAH90945 BC117341 AAI17342 BC117343 AAI17344 BX248023 CAD62346 BX248047 CAD62354 NM_152331 NP_689544
|
| Function |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. {ECO:0000250}.
|
| Subcellular Location |
Peroxisome {ECO:0000269|PubMed:16940157}.
|
| Tissue Specificity |
Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle. {ECO:0000269|PubMed:16940157}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids
|