Gene Symbol | ACOT4 |
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Entrez Gene | 122970 |
Alt Symbol | PTE-Ib, PTE1B, PTE2B |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA thioesterase 4 |
Other Description | PTE-2b|acyl-coenzyme A thioesterase 4|peroxisomal acyl coenzyme A thioester hydrolase Ib|peroxisomal acyl-CoA thioesterase 2B|peroxisomal long-chain acyl-CoA thioesterase Ib |
Swissprots | Q86TX1 Q96N88 Q17RF4 Q5BKT6 Q8N9L9 Q86TX0 |
Accessions | EAW81120 EAW81121 Q8N9L9 AK055797 BAB71017 AK094223 BAC04313 BC031799 AAH31799 BC090945 AAH90945 BC117341 AAI17342 BC117343 AAI17344 BX248023 CAD62346 BX248047 CAD62354 NM_152331 NP_689544 |
Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. {ECO:0000250}. |
Subcellular Location | Peroxisome {ECO:0000269|PubMed:16940157}. |
Tissue Specificity | Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle. {ECO:0000269|PubMed:16940157}. |
Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids |
ACOT4 CRISPR/Cas9 KO Plasmid (h) - sc-414194 from Santa Cruz Biotechnology
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ACOT4 HDR Plasmid (h) - sc-414194-HDR from Santa Cruz Biotechnology
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ACOT4 Double Nickase Plasmid (h) - sc-414194-NIC from Santa Cruz Biotechnology
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ACOT4 Double Nickase Plasmid (h2) - sc-414194-NIC-2 from Santa Cruz Biotechnology
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ACOT4 CRISPR Activation Plasmid (h) - sc-414194-ACT from Santa Cruz Biotechnology
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ACOT4 CRISPR Activation Plasmid (h2) - sc-414194-ACT-2 from Santa Cruz Biotechnology
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ACOT4 Lentiviral Activation Particles (h) - sc-414194-LAC from Santa Cruz Biotechnology
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ACOT4 Lentiviral Activation Particles (h2) - sc-414194-LAC-2 from Santa Cruz Biotechnology
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ACOT4 siRNA (h) - sc-72437 from Santa Cruz Biotechnology
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ACOT4 shRNA Plasmid (h) - sc-72437-SH from Santa Cruz Biotechnology
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ACOT4 shRNA (h) Lentiviral Particles - sc-72437-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2729 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2729 from Sigma-Aldrich
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ACOT4 siRNA (Human) - CRJ4719 from Cohesion Biosciences
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ACOT4 - MBS8211901 from MyBioSource
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shRNA set against Human ACOT4 (NM_152331.3) - SHH230434 from Creative biogene
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Human ACOT4 siRNA - orb275220 from Biorbyt
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ACOT4 shRNA Plasmid (Human) - CHJ4719 from Cohesion Biosciences
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ACOT4 miRNA 3'UTR clone - MiUTR3H-13212 from Creative biogene
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