| Gene Symbol |
LRSAM1
|
| Entrez Gene |
90678
|
| Alt Symbol |
CMT2P, RIFLE, TAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat and sterile alpha motif containing 1
|
| Other Description |
E3 ubiquitin-protein ligase LRSAM1|Tsg101-associated ligase
|
| Swissprots |
Q6UWE0 Q5VVV0 Q96MZ7 Q96GT5 Q96MX5 Q8NB40
|
| Accessions |
EAW87671 EAW87672 EAW87673 EAW87674 Q6UWE0 AF086398 AI364608 AK056203 BAB71119 AK056305 BAB71144 AK091589 BAC03703 AK097094 AK226106 AY358830 AAQ89189 BC009239 AAH09239 DA165729 DA393757 DA726792 DB165274 DB309230 Z44095 XM_006717316 XP_006717379 XR_929874 NM_001005373 NP_001005373 NM_001005374 NP_001005374 NM_001190723 NP_001177652 NM_138361 NP_612370
|
| Function |
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. {ECO:0000269|PubMed:15256501}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15256501}. Note=Displays a punctuate distribution and localizes to a submembranal ring.
|
| Tissue Specificity |
Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. {ECO:0000269|PubMed:22012984}.
|