| Gene Symbol |
PAG1
|
| Entrez Gene |
55824
|
| Alt Symbol |
CBP, PAG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
|
| Other Description |
Csk-binding protein|phosphoprotein associated with glycosphingolipid microdomains 1|phosphoprotein associated with glycosphingolipid-enriched microdomains 1|transmembrane adapter protein PAG|transmembrane adaptor protein PAG|transmembrane phosphoprotein Cbp
|
| Swissprots |
Q5BKU4 A8K1A3 Q9NYK0 Q9NWQ8 Q2M1Z9
|
| Accessions |
EAW87085 EAW87086 Q9NWQ8 AA766638 AF240634 AAF67343 AK000680 BAA91321 AK095177 AK289818 BAF82507 BC090931 AAH90931 BC112159 AAI12160 BX426120 CB960651 EU832160 ACE87510 EU832254 ACE86824 XM_011517561 XP_011515863 XM_011517562 XP_011515864 XM_011517563 XP_011515865 XM_011517564 XP_011515866 XM_011517565 XP_011515867 XM_011517566 XP_011515868 XR_928792 NM_018440 NP_060910
|
| Function |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.
|
| Tissue Specificity |
Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:16160011}.
|
![Western Blot: PAG Overexpression Lysate (Adult Normal) [NBL1-14068] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PAG.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2660_PAG%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14068-img0002.jpg)