PAG1

Gene Symbol	PAG1
Entrez Gene	55824
Alt Symbol	CBP, PAG
Species	Human
Gene Type	protein-coding
Description	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Other Description	Csk-binding protein|phosphoprotein associated with glycosphingolipid microdomains 1|phosphoprotein associated with glycosphingolipid-enriched microdomains 1|transmembrane adapter protein PAG|transmembrane adaptor protein PAG|transmembrane phosphoprotein Cbp
Swissprots	Q5BKU4 A8K1A3 Q9NYK0 Q9NWQ8 Q2M1Z9
Accessions	EAW87085 EAW87086 Q9NWQ8 AA766638 AF240634 AAF67343 AK000680 BAA91321 AK095177 AK289818 BAF82507 BC090931 AAH90931 BC112159 AAI12160 BX426120 CB960651 EU832160 ACE87510 EU832254 ACE86824 XM_011517561 XP_011515863 XM_011517562 XP_011515864 XM_011517563 XP_011515865 XM_011517564 XP_011515866 XM_011517565 XP_011515867 XM_011517566 XP_011515868 XR_928792 NM_018440 NP_060910
Function	Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.
Tissue Specificity	Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:16160011}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PAG protein fragment - ab56521 from Abcam Category Protein Source E. coli Species Human

PAG1 Antibody Blocking Peptide - LS-E23268 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PAG1 Protein - P5034 from Novus Biologicals Category Protein Prices $799.00 Sizes 100 µg Source E. coli Species Human

PAG1-Antibody-N-term-Blocking-Peptide - BP14211a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CBP peptide - orb72437 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CBP Blocking Peptide - abx062467 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig

PAG1 / Csk-binding protein - P5034 from Acris Antibodies Category Protein Prices $670.00 Sizes 100 µg Species Human

PAG1 fusion protein - ag13393 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PAG1, His-tagged - PAG1-30060TH from Creative Biomart Category Protein Source E. coli Species Human

EIF4E - NKX-870 from Reagent Proteins Category Protein Prices $364.00, $5,334.00 Sizes 10.00 µg, 1 mg Source E.coli

EIF4E 1-217aa - CMB-496 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

Recombinant Phosphoprotein Associated With Glycosphingolipid Microdomains 1 (PAG1) - RPG549Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Cbp/p300 - PPT-53484 from Nordic BioSite Category Protein

Recombinant CREB Binding Protein (CREBBP) - RPE002Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) - CSB-YP885746HU CSB-EP885746HU CSB-BP885746HU CSB-MP885746HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cbp/p300 Interacting Transactivator, With Glu/Asp Rich Carboxy Terminal Domain 1 Protein (Recombinant) - abx166985 from Abbexa Category Protein Source Human Species Human

Cbp/p300 Interacting Transactivator, Recombinant Protein - MBS2030505 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Phosphoprotein Associated With Glycosphingolipid Microdomains 1, Recombinant Protein - MBS2030092 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Phosphoprotein Associated With Glycosphingolipid Microdomains 1, Recombinant Protein - MBS2029305 from MyBioSource Category Protein Prices $195.00, $420.00, $650.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Eukaryotic Translation Initiation Factor 4E Human Recombinant - Pr20569 from ProMab Category Protein Prices $50.00, $130.00, $5,200.00 Sizes 2 μg, 10 μg, 1 mg Source Escherichia Coli. Species Human

PAG1 Recombinant Protein Antigen - NBP1-88173PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PAG1 Peptide, Human - M34GP11248H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Cbp/p300 Interacting Transactivator, With Glu/Asp Rich Carboxy Terminal Domain 1 (CITED1) - RPU53256 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

PAG1 Recombinant Protein Antigen - NBP2-56541PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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