PAG1

Gene Symbol PAG1
Entrez Gene 55824
Alt Symbol CBP, PAG
Species Human
Gene Type protein-coding
Description phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Other Description Csk-binding protein|phosphoprotein associated with glycosphingolipid microdomains 1|phosphoprotein associated with glycosphingolipid-enriched microdomains 1|transmembrane adapter protein PAG|transmembrane adaptor protein PAG|transmembrane phosphoprotein Cbp
Swissprots Q5BKU4 A8K1A3 Q9NYK0 Q9NWQ8 Q2M1Z9
Accessions EAW87085 EAW87086 Q9NWQ8 AA766638 AF240634 AAF67343 AK000680 BAA91321 AK095177 AK289818 BAF82507 BC090931 AAH90931 BC112159 AAI12160 BX426120 CB960651 EU832160 ACE87510 EU832254 ACE86824 XM_011517561 XP_011515863 XM_011517562 XP_011515864 XM_011517563 XP_011515865 XM_011517564 XP_011515866 XM_011517565 XP_011515867 XM_011517566 XP_011515868 XR_928792 NM_018440 NP_060910
Function Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.
Tissue Specificity Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:16160011}.

Cbp CRISPR/Cas9 KO Plasmid (h) - sc-401415 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp HDR Plasmid (h) - sc-401415-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp Double Nickase Plasmid (h) - sc-401415-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp Double Nickase Plasmid (h2) - sc-401415-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp CRISPR Activation Plasmid (h) - sc-401415-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp CRISPR Activation Plasmid (h2) - sc-401415-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp Lentiviral Activation Particles (h) - sc-401415-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp Lentiviral Activation Particles (h2) - sc-401415-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cbp siRNA (h) - sc-29952 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cbp shRNA Plasmid (h) - sc-29952-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cbp shRNA (h) Lentiviral Particles - sc-29952-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU024391 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16275 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16275 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PAG1 siRNA (Human) - CRJ0951 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PAG1 (NM_018440.3) - SHH370048 from Creative biogene

Category siRNA
Species Reactivities Human

Human PAG1 siRNA - orb271452 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PAG1 shRNA Plasmid (Human) - CHJ0951 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PAG1 miRNA 3'UTR clone - MiUTR1H-07465 from Creative biogene

Species Reactivities Human
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