DTX3L

Gene Symbol DTX3L
Entrez Gene 151636
Alt Symbol BBAP
Species Human
Gene Type protein-coding
Description deltex 3 like, E3 ubiquitin ligase
Other Description B-lymphoma- and BAL-associated protein|E3 ubiquitin-protein ligase DTX3L|deltex 3-like|rhysin 2|rhysin-2|rhysin2
Swissprots Q5MJP7 Q53ZZ3 B3KWH6 Q8TDB6
Accessions EAW79476 Q8TDB6 AF484416 AAL90859 AK025135 AK056406 AK093782 AK125086 BAG54138 AL833598 AY225123 AAP57517 AY780792 AAV98362 BC016846 BC040372 BC042191 AAH42191 BC060509 AAH60509 BX648267 BX648645 NM_138287 NP_612144
Function Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272}.
Subcellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.
Top Pathways Notch signaling pathway

DTX3L (N-16) - sc-102497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DTX3L (N-16): sc-102497. Western blot analysis of DTX3L expression in A-431 (A), HeLa (B), MCF7 (C) and HL-60 (D) nuclear extracts and A-431 whole cell lysate (E).

DTX3L (C-13) - sc-102496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DTX3L (C-13): sc-102496. Western blot analysis of DTX3L expression in A-431 nuclear extract.

DTX3L (45.Y) - sc-100627 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
DTX3L (45.Y): sc-100627. Western blot analysis of DTX3L expression in A-431 whole cell lysate.

Anti-DTX3L antibody - ab200222 from Abcam

Prices $359.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human fetal lung tissue labeling DTX3L with ab200222 at 1/100 dilution.

Anti-DTX3L antibody - ab70621 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DTX3L antibody (ab70621) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µg

Anti-DTX3L antibody - ab129449 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DTX3L antibody (ab129449) at 1/100 dilution + SK-BR-3 cell line lysates at 35 µg

Anti-DTX3L antibody - ab126040 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DTX3L antibody (ab126040) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-DTX3L antibody - ab58021 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DTX3L Antibody (aa75-125) - LS-C149413 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482, AP) - LS-C256336 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa3-111, clone 10C19, Azide-free) - LS-C183577 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C19

Anti-DTX3L Antibody (aa453-482, Biotin) - LS-C256338 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482, FITC) - LS-C256339 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482, APC) - LS-C256337 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482, PE) - LS-C256340 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482, Azide-free, HRP) - LS-C256341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa75-125) - LS-C287681 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa452-482) - LS-C320967 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (C-Terminus) - LS-C287683 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DTX3L Antibody (aa453-482) - LS-C167559 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DTX3L Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The DTX3L antibody detected the DTX3L protein (arrow).

Anti-DTX3L Antibody (clone 1D10) - LS-C133840 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1D10
DTX3L monoclonal antibody (M01), clone 1D10 Western Blot analysis of DTX3L expression in A-431.

DTX3L Antibody (1D10) - H00151636-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D10
Western Blot: DTX3L Antibody (1D10) [H00151636-M01] - DTX3L monoclonal antibody (M01), clone 1D10 Analysis of DTX3L expression in A-431.

DTX3L Antibody - NBP1-88699 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DTX3L Antibody [NBP1-88699] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Negative control (vector only transfected HEK293T lysate)Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY403351)

DTX3L Antibody - NB100-2873 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: DTX3L Antibody [NB100-2873] - Detection of Human and Mouse DTX3L/BBAP on HeLa whole cell lystate using NB100-2873. DTX3L/BBAP was also immunoprecipitated by another rabbit anti-DTX3L/BBAP antibody and NB100-2872.

DTX3L Antibody - NB100-2872 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: DTX3L Antibody [NB100-2872] - Detection of Human DTX3L/BBAP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DTX3L/BBAP antibody NB100-2872 used for IP at 3 mcg/mg lysate. DTX3L/BBAP was also immunoprecipitated by another rabbit anti-DTX3L/BBAP antibody and NB100-2873, which recognize downstream epitopes. Detection: Chemiluminescence with an exposure time of 3 minutes.
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