DTX3L

Gene Symbol	DTX3L
Entrez Gene	151636
Alt Symbol	BBAP
Species	Human
Gene Type	protein-coding
Description	deltex 3 like, E3 ubiquitin ligase
Other Description	B-lymphoma- and BAL-associated protein|E3 ubiquitin-protein ligase DTX3L|deltex 3-like|rhysin 2|rhysin-2|rhysin2
Swissprots	Q5MJP7 Q53ZZ3 B3KWH6 Q8TDB6
Accessions	EAW79476 Q8TDB6 AF484416 AAL90859 AK025135 AK056406 AK093782 AK125086 BAG54138 AL833598 AY225123 AAP57517 AY780792 AAV98362 BC016846 BC040372 BC042191 AAH42191 BC060509 AAH60509 BX648267 BX648645 NM_138287 NP_612144
Function	Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272}.
Subcellular Location	Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DTX3L protein fragment - ab165631 from Abcam Category Protein Source Wheat germ Species Human

DTX3L Antibody Blocking Peptide - LS-E4195 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DTX3L Protein - H00151636-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DTX3L-Antibody-Center-Blocking-Peptide - BP16451c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DTX3L / BBAP - H00151636-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DTX3L / BBAP - H00151636-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DTX3L fusion protein - Ag2568 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human DTX3L, GST-tagged - DTX3L-12193H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase DTX3L(DTX3L) - CSB-YP855054HU CSB-EP855054HU CSB-BP855054HU CSB-MP855054HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DTX3L / BBAP - TP307944 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DTX3L Recombinant Protein Antigen - NBP1-88699PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DTX3L Peptide, Human - M34GP04586H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase DTX3L (DTX3L), Recombinant Protein - MBS1443620 from MyBioSource Category Protein Prices $1,550.00, $1,550.00, $1,780.00, $1,780.00, $2,670.00, $2,670.00, $3,110.00, $3,110.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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