DTX3L

Gene Symbol DTX3L
Entrez Gene 151636
Alt Symbol BBAP
Species Human
Gene Type protein-coding
Description deltex 3 like, E3 ubiquitin ligase
Other Description B-lymphoma- and BAL-associated protein|E3 ubiquitin-protein ligase DTX3L|deltex 3-like|rhysin 2|rhysin-2|rhysin2
Swissprots Q5MJP7 Q53ZZ3 B3KWH6 Q8TDB6
Accessions EAW79476 Q8TDB6 AF484416 AAL90859 AK025135 AK056406 AK093782 AK125086 BAG54138 AL833598 AY225123 AAP57517 AY780792 AAV98362 BC016846 BC040372 BC042191 AAH42191 BC060509 AAH60509 BX648267 BX648645 NM_138287 NP_612144
Function Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272}.
Subcellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.
Top Pathways Notch signaling pathway

DTX3L CRISPR/Cas9 KO Plasmid (h) - sc-403953 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L HDR Plasmid (h) - sc-403953-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L Double Nickase Plasmid (h) - sc-403953-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L Double Nickase Plasmid (h2) - sc-403953-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L CRISPR Activation Plasmid (h) - sc-403953-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L CRISPR Activation Plasmid (h2) - sc-403953-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L Lentiviral Activation Particles (h) - sc-403953-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L Lentiviral Activation Particles (h2) - sc-403953-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DTX3L siRNA (h) - sc-78364 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DTX3L shRNA Plasmid (h) - sc-78364-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DTX3L shRNA (h) Lentiviral Particles - sc-78364-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DTX3L RNAi - H00151636-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU102991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU056301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7530 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7530 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DTX3L siRNA (Human) - CRJ5706 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DTX3L - MBS8204018 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DTX3L (NM_138287.3) - SHH281501 from Creative biogene

Category siRNA
Species Reactivities Human

Human DTX3L siRNA - orb276207 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DTX3L shRNA Plasmid (Human) - CHJ5706 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DTX3L miRNA 3'UTR clone - MiUTR4H-TG02892 from Creative biogene

Species Reactivities Human
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