| Gene Symbol | DTX3L |
|---|---|
| Entrez Gene | 151636 |
| Alt Symbol | BBAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | deltex 3 like, E3 ubiquitin ligase |
| Other Description | B-lymphoma- and BAL-associated protein|E3 ubiquitin-protein ligase DTX3L|deltex 3-like|rhysin 2|rhysin-2|rhysin2 |
| Swissprots | Q5MJP7 Q53ZZ3 B3KWH6 Q8TDB6 |
| Accessions | EAW79476 Q8TDB6 AF484416 AAL90859 AK025135 AK056406 AK093782 AK125086 BAG54138 AL833598 AY225123 AAP57517 AY780792 AAV98362 BC016846 BC040372 BC042191 AAH42191 BC060509 AAH60509 BX648267 BX648645 NM_138287 NP_612144 |
| Function | Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner. |
| Top Pathways | Notch signaling pathway |