SHC3

Gene Symbol SHC3
Entrez Gene 53358
Alt Symbol N-Shc, NSHC, RAI, SHCC
Species Human
Gene Type protein-coding
Description SHC (Src homology 2 domain containing) transforming protein 3
Other Description SH2 domain protein C3|SHC-transforming protein 3|SHC-transforming protein C|neuronal Shc|protein Rai|src homology 2 domain-containing transforming protein C3|src homology 2 domain-containing-transforming protein C3
Swissprots Q8TAP2 Q5T7I7 Q92529 Q9UCX5
Accessions EAW62759 EAW62760 Q92529 AK127258 BC026314 AAH26314 BC042431 BX538228 BX641139 D84361 BAA12322 DQ896663 ABM87662 HG502215 HG502216 HG502217 XM_011518785 XP_011517087 XM_011518786 XP_011517088 NM_016848 NP_058544
Function Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Tissue Specificity Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. {ECO:0000269|PubMed:8808684}.
Top Pathways Neurotrophin signaling pathway, Prolactin signaling pathway, Alcoholism, Estrogen signaling pathway, Bacterial invasion of epithelial cells

N-Shc (23) - sc-135996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
N-Shc (23): sc-135996. Western blot analysis of N-Shc expression in rat cerebrum tissue extract.

N-Shc (H-7) - sc-365598 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-Shc (H-7): sc-365598. Western blot analysis of N-Shc expression in SK-N-SH whole cell lysate.

N-Shc (H-140) - sc-28833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
N-Shc (H-140): sc-28833. Western blot analysis of N-Shc expression in SK-N-SH nuclear extract (A) and SH-SY5Y (B) and H4 (C) whole cell lysates.

N-Shc (N-19) - sc-6197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-Shc (N-19): sc-6197. Western blot analysis of N-Shc expression in BXPC-3 whole cell lysate.

Anti-SHC3 antibody - ab110973 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung tissue using SHC3 antibody (ab110973). On the left without blocking peptide and on the right with blocking peptide.

Anti-SHC3 antibody - ab192457 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SHC3 antibody (ab192457) at 1/1000 dilution + HepG2 cell lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

Anti-SHC3 antibody - ab139324 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SHC3 antibody (ab139324) at 1/500 dilution + Mouse brain total cell extract

Anti-SHC3 antibody - ab69355 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SHC3 antibody (ab69355) at 1/500 dilutionLane 1 : SHC3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Anti-SHC3 antibody - ab97972 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SHC3 antibody (ab97972) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SHC3 / SHCC Antibody (aa85-134) - LS-C135418 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SHC3 antibody LS-C135418 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.

Anti-SHC3 / SHCC Antibody (aa359-408) - LS-C107590 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SHC3 antibody LS-C107590 Western blot of HepG2 cell lysate.

Anti-SHC3 / SHCC Antibody (aa291-340) IHC-plus™ - LS-B8590 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SHC3 / SHCC antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8590 dilution 5 ug/ml.

SHC3 Antibody - NBP1-54810 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

SHC3 Antibody - H00053358-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SHC3 Antibody [H00053358-B01P] - Analysis of SHC3 expression in transfected 293T cell line by SHC3 polyclonal antibody. Lane 1: SHC3 transfected lysate(65.34 KDa). Lane 2: Non-transfected lysate.

SHC3 Antibody - H00053358-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SHC3 Antibody - H00053358-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SHC3 Antibody (1C11) - H00053358-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C11
Sandwich ELISA: SHC3 Antibody (1C11) [H00053358-M04] - Detection limit for recombinant GST tagged SHC3 is 0.03 ng/ml as a capture antibody.

Anti-SHC3 antibody produced in rabbit - HPA046656 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHC3:<B>Cat. No. HPA046656</B>: Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.

Anti-SHC3 antibody produced in rabbit - SAB4502207 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHC3: <B>Cat. No. SAB4502207</B>: Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Anti-SHC3 antibody. Cells on the left were treated with the Anti-SHC3 antibody. Cells on the right (negative control) were treated with both Anti-SHC3 antibody and the synthesized immunogen peptide.

Anti-SHC3 antibody produced in rabbit - SAB1401715 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-SHC3, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401715</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~64.00 kDa using SHC3 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-SHC3 antibody produced in mouse - SAB1407529 from Sigma-Aldrich

Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SHC3: <B>Cat. No. SAB1407529</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~65.3 kDa using SHC3 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Monoclonal Anti-SHC3 antibody produced in mouse - SAB1402588 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C11
<B>Immunoblotting</B><BR/>Monoclonal Anti-SHC3, antibody produced in mouse, clone 1C11, purified immunoglobulin: <B>Cat. No. SAB1402588</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-SHC3 antibody produced in rabbit - SAB2104794 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SHC3, antibody produced in rabbit: <B>Cat. No. SAB2104794</B>: Immunoblotting analysis of SHC3 in HepG2 cell lysate with SHC3 anitbody at 1 μg/mL.

SHC3 antibody - middle region (ARP56958_P050) - ARP56958_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SHC3-Antibody - AP50058 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HepG2 cell line ,using SHC3_HUMAN(C18734). C18734 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
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