| Gene Symbol |
SHC3
|
| Entrez Gene |
53358
|
| Alt Symbol |
N-Shc, NSHC, RAI, SHCC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SHC (Src homology 2 domain containing) transforming protein 3
|
| Other Description |
SH2 domain protein C3|SHC-transforming protein 3|SHC-transforming protein C|neuronal Shc|protein Rai|src homology 2 domain-containing transforming protein C3|src homology 2 domain-containing-transforming protein C3
|
| Swissprots |
Q8TAP2 Q5T7I7 Q92529 Q9UCX5
|
| Accessions |
EAW62759 EAW62760 Q92529 AK127258 BC026314 AAH26314 BC042431 BX538228 BX641139 D84361 BAA12322 DQ896663 ABM87662 HG502215 HG502216 HG502217 XM_011518785 XP_011517087 XM_011518786 XP_011517088 NM_016848 NP_058544
|
| Function |
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
|
| Tissue Specificity |
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. {ECO:0000269|PubMed:8808684}.
|
| Top Pathways |
Neurotrophin signaling pathway, Prolactin signaling pathway, Alcoholism, Estrogen signaling pathway, Bacterial invasion of epithelial cells
|