| Gene Symbol |
PRSS3
|
| Entrez Gene |
5646
|
| Alt Symbol |
MTG, PRSS4, T9, TRY3, TRY4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protease, serine, 3
|
| Other Description |
brain trypsinogen|mesotrypsin|mesotrypsinogen|pancreatic trypsinogen III|protease, serine, 4 (trypsin 4, brain)|trypsin III|trypsin IV|trypsin-3|trypsinogen 4|trypsinogen 5|trypsinogen IV
|
| Swissprots |
A8CED1 E7ES07 Q5VXV0 P15951 P35030 Q9UQV3 F8W7P3 Q6ISJ4 A8CED3 Q15665 A9Z1Y4
|
| Accessions |
AAC13322 EAW58481 EAW58482 EAW58483 EAW58484 P35030 AB298285 BAF80324 AB298286 BAF80325 AY052783 AAL14243 BC030238 AAH30238 BC069476 AAH69476 BC069494 AAH69494 D45417 BAA08257 HQ448195 ADQ32676 X15505 CAA33527 X71345 CAA50484 X72781 CAB58178 XM_011517965 XP_011516267 NM_001197097 NP_001184026 NM_001197098 NP_001184027 NM_002771 NP_002762 NM_007343 NP_031369
|
| Function |
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:14507909}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}.
|
| Top Pathways |
Protein digestion and absorption, Pancreatic secretion, Influenza A, Neuroactive ligand-receptor interaction
|