Gene Symbol | PRSS3 |
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Entrez Gene | 5646 |
Alt Symbol | MTG, PRSS4, T9, TRY3, TRY4 |
Species | Human |
Gene Type | protein-coding |
Description | protease, serine, 3 |
Other Description | brain trypsinogen|mesotrypsin|mesotrypsinogen|pancreatic trypsinogen III|protease, serine, 4 (trypsin 4, brain)|trypsin III|trypsin IV|trypsin-3|trypsinogen 4|trypsinogen 5|trypsinogen IV |
Swissprots | A8CED1 E7ES07 Q5VXV0 P15951 P35030 Q9UQV3 F8W7P3 Q6ISJ4 A8CED3 Q15665 A9Z1Y4 |
Accessions | AAC13322 EAW58481 EAW58482 EAW58483 EAW58484 P35030 AB298285 BAF80324 AB298286 BAF80325 AY052783 AAL14243 BC030238 AAH30238 BC069476 AAH69476 BC069494 AAH69494 D45417 BAA08257 HQ448195 ADQ32676 X15505 CAA33527 X71345 CAA50484 X72781 CAB58178 XM_011517965 XP_011516267 NM_001197097 NP_001184026 NM_001197098 NP_001184027 NM_002771 NP_002762 NM_007343 NP_031369 |
Function | Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:14507909}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}. |
Top Pathways | Protein digestion and absorption, Pancreatic secretion, Influenza A, Neuroactive ligand-receptor interaction |
Trypsin-3 CRISPR/Cas9 KO Plasmid (h) - sc-402362 from Santa Cruz Biotechnology
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Trypsin-3 HDR Plasmid (h) - sc-402362-HDR from Santa Cruz Biotechnology
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Trypsin-3 Double Nickase Plasmid (h) - sc-402362-NIC from Santa Cruz Biotechnology
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Trypsin-3 Double Nickase Plasmid (h2) - sc-402362-NIC-2 from Santa Cruz Biotechnology
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Trypsin-3 CRISPR Activation Plasmid (h) - sc-402362-ACT from Santa Cruz Biotechnology
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Trypsin-3 CRISPR Activation Plasmid (h2) - sc-402362-ACT-2 from Santa Cruz Biotechnology
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Trypsin-3 Lentiviral Activation Particles (h) - sc-402362-LAC from Santa Cruz Biotechnology
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Trypsin-3 Lentiviral Activation Particles (h2) - sc-402362-LAC-2 from Santa Cruz Biotechnology
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Mesotrypsinogen siRNA (h) - sc-61020 from Santa Cruz Biotechnology
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Mesotrypsinogen shRNA Plasmid (h) - sc-61020-SH from Santa Cruz Biotechnology
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Mesotrypsinogen shRNA (h) Lentiviral Particles - sc-61020-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU113371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17536 from Sigma-Aldrich
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PRSS3 siRNA (Human) - CRH3805 from Cohesion Biosciences
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Trypsin 3/PRSS3 RNAi - H00005646-R01 from Novus Biologicals
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Trypsin-3 CRISPR/Cas9 KO Plasmid (h2) - sc-402362-KO-2 from Santa Cruz Biotechnology
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Trypsin-3 HDR Plasmid (h2) - sc-402362-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PRSS3 (NM_002771.3) - SHH384432 from Creative biogene
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Human PRSS3 siRNA - orb264307 from Biorbyt
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PRSS3 shRNA Plasmid (Human) - CHH3805 from Cohesion Biosciences
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PRSS3 miRNA 3'UTR clone - MiUTR4H-TG07106 from Creative biogene
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