| Gene Symbol |
TRIM27
|
| Entrez Gene |
5987
|
| Alt Symbol |
RFP, RNF76
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 27
|
| Other Description |
RFP transforming protein|RING finger protein 76|ret finger protein|tripartite motif protein TRIM27|tripartite motif-containing 27|tripartite motif-containing protein 27|zinc finger protein RFP
|
| Swissprots |
P14373 Q9BZY6 Q5ST26 A2BE15 Q9UJL3 Q6NXR9 Q5RJA8 Q6LA73
|
| Accessions |
AAF32265 CAB06480 CAI19959 EAX03176 EAX03177 P14373 AB209885 BAD93122 AF230393 AAG50172 AF230394 AAG50173 AJ420519 AX776009 CAE11704 AX776011 CAE11705 BC013580 AAH13580 BC066924 AAH66924 DQ890982 ABM81908 DQ894156 ABM85082 J03407 AAA36564 NM_006510 NP_006501 NM_030950
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Early endosome {ECO:0000269|PubMed:1437549, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:9247190}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269|PubMed:23452853}.
|
| Tissue Specificity |
Expressed in testis namely within the seminiferous tubules. {ECO:0000269|PubMed:12445133}.
|